Methods and compositions to inhibit keratinocyte proliferation

Details Methods and compositions to inhibit keratinocyte proliferation Methods and compositions to inhibit keratinocyte proliferation

1996-07-30

1998-05-05

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514859, 514861, 514863, 514864, A61K 31555

Patent

active

057474826

ABSTRACT:
Disclosed are methods to inhibit mammalian skin cell proliferation and, in particular, human keratinocyte proliferation by the topical administration of neutral gallium complexes.

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patent: 4704277 (1987-11-01), Bockman et al.
patent: 5175006 (1992-12-01), Matkovic et al.
patent: 5258376 (1993-11-01), Bernstein
Adamson, et al., "Studies on the Antitumor Activity of Gallium Nitrate (NSC-15200) and Other Group IIIa Metal Salts", Chemotherapy Reports, Part 1, 59:599-610 (1975).
Landegren, "Measurement of Cell Numbers by Means of the Endogenous Enzyme Hexosaminidase. Applications to Detection of Lymphokines and Cell Surface Antigens", J. Immunol. Methods, 67:379-388 (1984).
Matkovic, et al., "Gallium Prevents Adjuvant Arthritis in Rats and Interferes with Macrophage/T-Cell Function in the Immune Response", Current Therap. Res., 50(2):255-267 (1991).
Whitacre, et al., "Suppression of Experimental Autoimmune Encephalomyelitis by Gallium Nitrate", J. Neuroimmuno., 39:175-182 (1992).
Warrell, Jr. et al., "Gallium in the Treatment of Hypercalcemia and Bone Metastasis", in Important Advances in Oncology 1989, DeVita, Jr., Editor, J.P. Lippincott Company, Philadelphia, PA. (1989).
Wilkinson, et al., "Nerve Growth Factor Increases the Mitogenicity of Certain Growth Factors for Cultured Human Keratinocytes: A Comparison with Epidermal Growth Factor", Exper. Dermatol., 3:239-245 (1994).

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