Methods and compositions to enhance the cytoprotective effects o

Details Methods and compositions to enhance the cytoprotective effects o Methods and compositions to enhance the cytoprotective effects o

1998-01-16

1999-10-26

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514 2, 514458, 424702, A61K 3156, A61K 3800, A61K 31355, A61K 3304

Patent

active

059729236

ABSTRACT:
The present invention concerns methods and compositions for enhancing the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants.

REFERENCES:
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Lacort, Mercedes, et al., "Protective Effect of Estrogens and Catecholestrogens Against Peroxidative Membrane Damage in vitro", Lipids, vol. 30, No. 1, 1995, pp. 141-146.
Massafra, Cosimo, et al., "Antioxidant Erythrocyte Enzyme Activities During Oral Contraception", Contraception, vol. 47, 1993, pp. 591-596.
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Ruiz-Larrea, Begona, et al. "Effects of Estrogens on the Redox Chemistry of Iron: A possible mechanism of antioxidant action of estrogens", Steroids, vol. 60. Nov. 1995, pp. 780-783.
Wander, Rosemary C., et al., "Effects of interaction of RRR-.alpha.-Tocopheryl acetate and fish oil on low-density-lipoprotein oxidation in postmenopausal women with and without hormone-replacement therapy", American Journal of Clinical Nutrition, vol. 63, 1996, pp. 184-193.

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