Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-05-25
1997-02-04
Housel, James C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4241841, 4242511, 435 72, 435 732, 435 711, 435 712, 435243, 4352521, 436543, 5303882, 5303884, 530412, 530413, 935106, 935108, 935109, 935110, C12P 2106
Patent
active
055996930
ABSTRACT:
The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that have been found by the inventors to have a variety of useful properties. These proteins, termed OMPs ("Outer Membrane Proteins"), are characterized as having molecular weights of 30, 80 and 100 kD, respectively. Studies set forth herein demonstrate that monoclonal antibodies directed against these proteins confer a protective effect against infection by Moraxella catarrhalis organisms in animal models, demonstrating the potential usefulness of such antibodies in conferring passive immunity as well as the potential usefulness of these OMPs, or variants thereof, in the preparation of vaccines. Also disclosed are DNA segments encoding these OMPs, methods for preparing the antigens, or variants, through the application of recombinant DNA techniques, as well as diagnostic methods and embodiments.
REFERENCES:
Murphy, T. F., "Studies of the Outer Membrane Proteins of Branhamella catarrhalis," Am. J. Med., 88(suppl. 5A): 41S-45S, 1990.
Goldblatt et al., "Branhamella cattarhalis: Antigenic Determinants and the Development of the IgG Subclass Response in Childhood," J. Infect. Dis., 162:1128-1135, 1990.
Consensus, Paediatr. Infect. Dis. J. 8(1):S94-S97, 1989.
Murphy & Loeb, "Isolation of the outer membrane of Branhamella catarrhalis," Microbial Pathogenesis, 6:159-174, 1989.
Murphy, T. F., "The surface of Branhamella catarrhalis: a systematic approach to the surface antigens of an emerging pathogen," Paediatr. Infect. Dis. J. 8(1):S75-S77, 1989.
Murphy & Bartos, "Surface-Exposed and Antigenically Conserved Determinants of Outer Membrane Proteins of Branhamella catarrhalis," Infect. Immun. 57(10):2938-2941, 1989.
Bartos & Murphy, "Comparison of the Outer Membrane Proteins of 50 Strains of Branhamella catarrhalis," J. Infect. Dis. 158(4):761-765, 1988.
Eliasson, I., "A Protein Antigen Characteristic of Branhamella catarrhalis," Acta path. Microbiol. Scand. Sect. B., 88:281-286, 1980.
Dialog Search Report.
Helminen et al., "Molecular Cloning of a Gene Encoding a Surface-Exposed Outer Membrane Protein of Moraxella Catarrhalis", Abstract of the 1991 ICAA, 31 (O), p. 145, Abstract No. 278.
International Search Report, mailed 27 Nov., 1992.
Beaulieu & Roy, "Construction of a Species-Specific DNA Probe for Branhamella catarrhalis," 89th Annual Meeting of the American Society for Microbiology, New Orleans, Louisiana, USA, May 14-18, 1989. Abstr. Annu. Meet. Am. Soc. Microbiol. 89 (O), 1989. p. 124, Abstract #D-249.
Bhushan & Murphy, "Molecular Characterization of Outer Membrane Protein E. of Branhamella catarrhalis: a Potential Vaccine Candidate," 91st General Meeting of the American Society for Microbiology 1991, Dallas, Texas, USA, May 5-9, 1991. Abstr. Gen. Meet. Am. Soc. Microbiol. 91 (O). 1991. p. 57, Abstract #B-191.
Black & Wilson, "Immunoglobulin G (IgG) Serological Response to Branhamella Catarrhalis in Patients with Acute Bronchopulmonary Infections," J. Clin. Pathol., 41:329-333, (1988).
Chapman et al., "Development of Bactericidal Antibody During Branhamella catarrhalis Infection," J. of Infect. Dis., 151(5):878-882, (1985).
Hanson, M. S. et al., 1989, Expression of the Heat-Modifiable Major Outer Membrane Protein of Haemophilus influenzae Type b is Unrelated to Virulence, Infection and Immunity, 57(6):1639-1646.
Klingman, K. L. and Murphy, T. F., 1992, Identification and purification of the lipooligosaccharide-associated high molecular weight outer membrane protein (HMW-OMP) of Branhamella catarrhalis, Abstract of the 92nd General Meeting of the American Society for Microbiology, p. 90, B-388.
Shenep, J. L., et al., 1983, Further Studies of the Role of Noncapsular Antibody in Protection Against Experimental Haemophilus influenzae Type b Bacteremia, Infection and Immunity 42(1):257-263.
Srikumar, R., et al., 1992, Monoclonal antibodies specific to porin of Haemophilus influenzae type b: localization of their cognate epitopes and tests of their biological activities, Molecular Microbiology 6(5): 665-676.
Yogev, R. and Hansen, E. J., 1987, Dissociation of Virulence and Protection from Infection by Mutant Analysis in Haemophilus influenzae Type b, Infection and Immunity 55(B):1944-1947.
Hansen Eric J.
Helminen Merja
Maciver Isobel
American Cyanamid Company
Housel James C.
Murthy Prasad
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