Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-09-26
2006-09-26
Balasubramanian, Venkataraman (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S197000, C544S198000, C544S206000, C544S209000, C544S219000, C540S480000, C540S598000, C514S183000, C514S212080
Reexamination Certificate
active
07112587
ABSTRACT:
The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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Alexander Christopher W.
Kumar Potlapally Rajendar
Om Reddy Gaddam
Pal Manojit
Pillarisetti Sivaram
Reddy US Therapeutics Inc.
Womble Carlyle Sandridge & Rice PLLC
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