Drug – bio-affecting and body treating compositions – Topical body preparation containing solid synthetic organic...
Patent
1992-02-13
1995-11-28
Webman, Edward
Drug, bio-affecting and body treating compositions
Topical body preparation containing solid synthetic organic...
424 7817, 424 45, 424 7806, 424422, 424DIG13, 514917, 514975, 935 52, 935 93, 935 95, 604 20, 252 70, 106 13, A61K 906, A61K 912, A61K 3177
Patent
active
054705681
ABSTRACT:
Novel methods for prophylaxis and treatment of tissue damage resulting from cell membrane permeabilization are disclosed. Compositions comprising a surface active copolymer are employed to prevent permeabilization or to promote membrane repair. Methods for enhancement of cell survival following membrane permeabilization in vitro are also disclosed, along with methods for increasing the efficacy of transfection of cells with foreign exogenous macromolecules, in particular DNA, also involving treatment of permeabilized cells with a surface active copolymer. Also disclosed are novel methods for prophylaxis and treatment of tissue damage, and for enhancement of cell survival and transfection efficacy, using a surface active copolymer in combination with high energy phosphate compounds which are capable of recharging cellular energy stores and thereby potentiating cell repair and survival. Compositions comprising surface active copolymers for intravenous, intramuscular, and topical use are also disclosed, along with novel compositions comprising a combination of a surface active copolymer and a high energy phosphate compound.
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ARCH Development Corporation
Webman Edward
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