Methods and compositions of a bioartificial kidney suitable for

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...

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435325, 435347, 435369, 435371, 435373, 435395, C12N 500, C12N 502, C12N 506, C12N 508

Patent

active

061501646

ABSTRACT:
A novel cell seeded hollow fiber bioreactor is described as a potential bioartificial kidney. Endothelial cells along with pericyte, vascular smooth muscle, and/or mesangial cells or any mesenchymally derived support cells are seeded along a hollow fiber in a perfused bioreactor to reproduce the ultrafiltration function and transport function of the kidney. Maintenance of tissue specific function and ultrastructure suggest that this bioreactor provides an economical device for treating renal failure.

REFERENCES:
patent: 5429938 (1995-07-01), Humes
patent: 5516680 (1996-05-01), Naughton et al.
patent: 5549674 (1996-08-01), Humes et al.
patent: 5686289 (1997-11-01), Humes et al.

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