Methods and compositions involving polyhydroxylated polyiodo non

Details Methods and compositions involving polyhydroxylated polyiodo non Methods and compositions involving polyhydroxylated polyiodo non

1983-10-20

1986-04-22

Waltz, Thomas A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564156, 564157, 564167, 424 5, A61K 4904, C07C10324, C07C10376

Patent

active

045844011

ABSTRACT:
Methods and compositions are provided for preparing polyhydroxylated polyiodo non-ionic contrast media. Particularly, substituted polyiodobenzamides are prepared, wherein the benzamide nitrogen is polyhydroxylated by allylic substitution on the nitrogen and oxidation of the olefinic group to provide for polyhydroxyl substitution. Amino substituents on the benzamide may be polyhydroxylated by allyl substitution or acryl substitution. All of the olefins may be oxidized simultaneously to glycols to provide for water soluble relatively non-toxic contrast media in efficient economical processes. Alternatively, the same compounds can be synthesized by alkylating N-acylbenzamide with polyacetoxyalkyl or dioxolanylalkyl halides, followed by removal of the protective groups.

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patent: 3702866 (1972-11-01), Salvesen et al.
patent: 3953501 (1976-04-01), Klieger et al.
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patent: 4062934 (1977-12-01), Tilly et al.
patent: 4250113 (1981-02-01), Nordal et al.
patent: 4341756 (1982-07-01), Sovak et al.
patent: 4352788 (1982-10-01), Felder et al.

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