Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2004-06-21
2010-06-22
Robinson, Hope A (Department: 1652)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S300000, C435S007100, C435S220000
Reexamination Certificate
active
07741438
ABSTRACT:
The present invention concerns the methods and compositions involving endopeptidase enzymes, especially PepO2 and PepO3 fromL. helveticus, and their use in reducing bitterness by cleaving bitter peptides. In particular embodiments of the invention, these methods and compositions apply to the cheesemaking process. The invention also concerns the use of PepO2 and/or PepO3 polypeptides in the treatment or prevention of celiac sprue or as a food additive.
REFERENCES:
patent: 4001133 (1977-01-01), Sorgenfrei et al.
patent: 4017410 (1977-04-01), Sorgenfrei et al.
patent: 4063893 (1977-12-01), Stoulil et al.
patent: 4739906 (1988-04-01), LoTurco
patent: 5020917 (1991-06-01), Homan
patent: 5106631 (1992-04-01), Turner et al.
patent: 5234268 (1993-08-01), Homan
patent: 5356639 (1994-10-01), Jameson et al.
patent: 5387422 (1995-02-01), Handel et al.
patent: 5395631 (1995-03-01), Sweeney
patent: 5429829 (1995-07-01), Ernster, Sr.
patent: 5462755 (1995-10-01), Mehnert
patent: 5469880 (1995-11-01), Zimmerly
patent: 5505979 (1996-04-01), Sevenich
patent: 5547691 (1996-08-01), Kjaer et al.
patent: 5554398 (1996-09-01), Chen et al.
patent: 5593598 (1997-01-01), McGinness et al.
patent: 5635228 (1997-06-01), Sponholtz
patent: 5643621 (1997-07-01), Mehnert
patent: 5688542 (1997-11-01), Tortosa
patent: 5776351 (1998-07-01), McGinness et al.
patent: 5853786 (1998-12-01), Anbarci et al.
patent: 5888966 (1999-03-01), Larsen et al.
patent: 5948459 (1999-09-01), Telford
patent: 5988052 (1999-11-01), Abler
patent: 6020324 (2000-02-01), Jamas et al.
patent: 6026740 (2000-02-01), Abler
patent: 6066610 (2000-05-01), Sramek
patent: 6103277 (2000-08-01), Leufstedt et al.
patent: 6120809 (2000-09-01), Rhodes
patent: 6127142 (2000-10-01), Harboe et al.
patent: 6139889 (2000-10-01), Guinee et al.
patent: 6140078 (2000-10-01), Sanders et al.
patent: 6183804 (2001-02-01), Moran et al.
patent: 6242036 (2001-06-01), Han et al.
patent: 6258390 (2001-07-01), Budtz
patent: 6270823 (2001-08-01), Jolkin
patent: 6297042 (2001-10-01), Hicks
patent: 6299896 (2001-10-01), Cooper et al.
patent: 6335040 (2002-01-01), Hoier et al.
patent: 6399121 (2002-06-01), Nielsen
patent: 6401604 (2002-06-01), Rose et al.
patent: 6410076 (2002-06-01), Van Der Meulen
patent: 6413568 (2002-07-01), Rietveld
patent: 6416797 (2002-07-01), Han et al.
patent: 6443379 (2002-09-01), Lassmann
patent: 6455092 (2002-09-01), Begueria
patent: 6458394 (2002-10-01), Talbott
patent: 6465033 (2002-10-01), Menninga et al.
patent: 6468570 (2002-10-01), Haddad et al.
patent: 6475290 (2002-11-01), Jones
patent: 6475538 (2002-11-01), Thakar et al.
patent: 6485762 (2002-11-01), Rizvi et al.
patent: 6548089 (2003-04-01), Hoier et al.
patent: 6551635 (2003-04-01), Nielsen
patent: 6558716 (2003-05-01), Smith et al.
patent: 6572901 (2003-06-01), Han et al.
patent: 6686324 (2004-02-01), Ramirez et al.
Seffernick et al. (J. Bacteriology, vol. 183, pp. 2405-2410, 2001).
Wells, Biochemistry, vol. 29, pp. 8509-8517, 1990.
Guo et al. (PNAS, vol. 101, No. 25, pp. 9205-9210, 2004.
Bartels et al., “Accelerated ripening of Gouda cheese. II. Effect of freeze-shockedLactobacillus helveticuson proteolysis and flavor development,”Milchwissenschaft, 42(3):139-144, 1987.
Bartels et al., “Accelerated ripening of Gouda cheese. I. Effect of heat-shocked thermophilic lactobacilli and streptococci on proteolysis and flavor development,”Milchwissenschaft, 42(2):83-88, 1987.
Broadbent et al, “Contribution ofLactococcus lactiscell envelope proteinase sepcificity to peptide accumulation and bitterness in reduced-fat cheddar cheese,”Appl. Environ. Microbiol., 68(4):1778-1785, 2002.
Broadbent et al., “Peptide accumulation and bitterness in cheddar cheese made using single-strainLactococcus lactisstarters with distinct proteinase specificities,”J. Dairy Sci., 81:327-337, 1998.
Chavagnat et al, “Purification, characterization, cloning and sequencing of the gene encoding oligopeptidase PepO fromStreptococcus therrnophilusA,”FEMS Microbiol Lett., 191:79-85, 2000.
Chen and Okayama, “High-efficiency transformation of mammalian cells by plasmid DNA,”Mol Cell Biol., 7(8):2745-2752., 1987.
Chen and Steele, “Genetic characterization and physiological role of endopeptidase O fromLactobacillus helveticusCNRZ32,”Appl. Environ. Microbiol., 64(9):3411-3415, 1998.
Chen et al., “Identification and characterization of Pep O2 fromLactobacillus helveticusCNRZ32, an enzyme involved in the hydrolysis of a β-casein derived bitter peptide,”J. Anim. Sci., 78(Supp. 1):401, 2000.
Chen et al., “Identification and characterization ofLactobacillus helveticusPepO2, an endopeptidase with post-proline specificity,”Appl. Environ. Microbiol., 69(2):1276-1282, 2003.
Christensen et al., “Hydrolysis of casein-derived peptides αs1-casein(fl-9) and β-casein(fl93-209) byLactobacillus helveticuspeptidase deletion mutants indicates the presence of a previously undetected endopeptidase,”Appl. Environ. Microbiol., 69(2):1283-1286, 2003.
Christensen et al., “Peptidase and amino acid catabolism in lactic acid bacteria,”Antonie van Leeuwenhoek, 76:217-246, 1999.
Christensen, “Peptidases ofLactobacillus helveticus: role in physiology and casein hydrolysis,” In:Peptidases of Lactobacillus helveticus: Role in Physiology and Casein Hydrolysis, University of Wisconsin-Madison, 2000.
Christensson et al., “Cloning and expression of an oligopeptidase, PepO, with novel specificity fromLactobacillus rhamnosusHN001 (DR20),”Appl. Environ. Microbiol., 68(1):254-262, 2002.
Exterkate and Alting, “The role of starter peptidases in the initial proteolytic events leading to amino acids in Gouda cheese,”Int. Dairy J., 5:15-28, 1995.
Fenster and Steele, “Characterization of an arylesterase fromLactobacillus helveticusCNRZ.32,”J. Appl. Microbiol., 88(4):572-583, 2000.
Fenster et al., “Characterization of a thiol-dependent endopeptidase fromLactobacillus helveticusCNRZ32,”J. Bacteriol., 179(8):2529-2533, 1997.
Froeliger et al., “Streptococcus parasanguispepO encodes an endopeptidase with structure and activity similar to those of enzymes that modulate peptide receptor signaling in Eukaryotic cells,”Infect. Immun., 67(10):5206-5214, 1999.
Gomez et al., “Debittering activity of peptidases from selectedlactobacillistrains in model cheeses,”Milchwissenschaft, 51:315-319, 1996.
Hassan et al., “Factors affecting capsule size and production by lactic acid bacteria used as dairy starter cultures,”Int. J. Food Microbiol., 64(1-2):199-203, 2001.
Hellendoom et al., “Cloning and analysis of the pepV dipeptidase gene ofLactococcus lactisMG1363,”J. Bacteriol, 179(11):3410-3415, 1999.
Kaminogawa et al., “Identification of low molecular weigh peptides in Gouda-type cheese and evidence for the formulation of these peptides from 23 N-terminal residues of αsl-casein by proteinases ofStreptococcus cremorisH61,”J. Food Sci., 51(5):1253-1264, 1986.
Khalid and Marth, “Purification and partial characterization of a prolyl-dipeptidyl aminopeptidase fromLactobacillus helveticusCNRZ 32,”Appl. Environ. Microbiol., 56(2):381-388, 1990.
Khalid et al., “Peptide hydrolases ofLactobacullus helveticusandLactobacullus delbrueckiissp.bulgaricus,” J. Dairy Sci., 74:29-45, 1991.
Kok and De Vos, In:Genetics and Biotechnology of Lactic Acid Bacteria, Glasson and de Vos (Eds.), Blackie Academic and Professional, Glasgow, 1994.
Kunji et al., “The proteolytic systems of lactic acid bacteria,”Antonie van Leeuwenhoek, 70:187-221, 1996.
Lee et al., “Removal of bitterness from the bitter peptides extracted from cheddar cheese with peptidases fromLactococcus lactisssp.cremorisSK 111,”J. Dairy Sci., 79:1521-1528, 1996.
Lemieux and Simard, “Bitter flavour in dairy products I. A review of the factors likely to influence its development
Broadbent Jeffrey R.
Sridhar Vidya R.
Steele James L.
Fulbright & Jaworski L.L.P.
Robinson Hope A
Utah State University
Wisconsin Alumni Research Foundation
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