Methods and compositions involved in cell growth, neoplasia and

Details Methods and compositions involved in cell growth, neoplasia and Methods and compositions involved in cell growth, neoplasia and

1995-06-06

1997-12-16

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

530350, C12N 1500, C07K 1400

Patent

active

056984278

ABSTRACT:
A peptide, Hel-N1, which can bind to a 3'-untranslated mRNA sequence (which encompasses the "instability sequence") that is uniquely present in the messenger RNAs that encode oncoproteins and lymphokines, and mediates the specific destruction of the messenger RNAs, is described. Full-length Hel-N1 is capable of suppressing cell growth and causing cellular differentiation. Hel-N1 possess three RNA recognition motifs. One of these forms an RNA-binding domain which, when transfected alone into cells, causes them to undergo rapid growth.

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Meijlink et al PNAS 82: 4987, 1985.
Shaw et al Cell 48: 659, 1986.
Mashall Science 270: 1751, 1995.
Coughlan New Scientist, 25 Nov. 1995 pp. 14-15.
Donahue et al JEM 176: 1125, 1992.
Orkin & Motulsky "Report & Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 7, 1995.

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