Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-08-23
2005-08-23
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C435S069100, C435S320100, C435S007210, C435S091200, C435S235100, C536S023100, C536S023400, C530S300000, C530S350000
Reexamination Certificate
active
06933108
ABSTRACT:
Methods and compositions are provided for at least slowing the progression of a filovirus mediated disease condition in a host. In the subject methods, an effective amount of an agent that at least reduces the amount of folate receptor mediated filovirus cell entry is administered to the host. The subject methods find use in both the prevention and treatment of filovirus associated disease conditions, including Marburg and Ebola-Zaire virus mediated disease conditions.
REFERENCES:
patent: 5416016 (1995-05-01), Low et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5837533 (1998-11-01), Boutin
patent: 6093382 (2000-07-01), Wedeking et al.
patent: 6589730 (2003-07-01), Larocca et al.
Chan et al. (2000) “Distinct Mechanisms of Entry by Envelope Glycoproteins of Marburg and Ebola (Zaire) Viruses.”Journal of Virology, vol. 74(10):4933-4937.
Elwood et al. (1997) “The Divergent 5′ Termini of the α Human Folate Receptor (hFR) mRNAs Originate from Two Tissue-Specific Promoters and Alternative Splicing: Characterization of the α hFR Gene Structure.”Biochemistry, vol. 36:1467-1478.
Genbank Accession No. U31033, deposited Apr. 12, 1996.
Genbank Accession No. NC_002549, deposited Feb. 10, 1999.
Genbank Accession No. NC_001608, deposited Jun. 9, 2000.
Genbank Accession No. NM_016731, deposited Nov. 2, 2000.
Roberts et al. (1997) “Tissue-specific promoters of the α human folate receptor gene yield transcripts with divergent 5′ leader sequences and different translational efficiencies.”Biochem. J., vol. 326(Pt. 2):439-447.
Roberts et al. (1998) “Role of Individual N-Linked Glycosylation Sites in the Function and Intracellular Transport of the Human α Folate Receptor.”Archives of Biochemistry and Biophysics, vol. 351(2):227-235.
Sadasivan et al. (1989) “The Complete Amino Acid Sequence of a Human Folate Binding Protein from KB Cells Determined from the cDNA.”The Journal of Biological Chemistry, vol. 264(10):5806-11.
Xu et al. (1998) “Immunization for Ebola virus infection.”Nature Medicine, vol. 4(1):37-42.
Chan Stephen
Goldsmith Mark A.
Basi Nirmal
Borden Paula A.
Bozicevic Field & Francis LLP
Field Bret E.
Pak Michael
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