Methods and compositions for use in characterizing multiple scle

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 24, 435 23, 435 4, 435975, C12Q 142, C12Q 137, C12Q 100

Patent

active

060805544

ABSTRACT:
Methods are providing for characterizing multiple sclerosis disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have multiple sclerosis. The sample is then assayed for the presence of both high and low molecular proteins having RNAse L activity and a ratio of these two proteins is derived. The resultant ratio is then used to characterize the MS disease activity in the subject, e.g. to confirm an initial MS diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.

REFERENCES:
patent: 5866119 (1999-02-01), Bandman et al.
Charachon, Guillaume, et al., "Phosphorothioate Analogues (2'-5')(A).sub.4 : Agonist And Antagonist Activities In Intact Cells," Biochemistry (1990) vol. 29:2550-2556.
Suhadolink, Robert J., et al., "Biochemical Evidence For A Novel Low Molecular Weight 2-5A-Dependent Rnase L In Chronic Fatigue Syndrome," Journal Of Interferon And Cytokine Research (1997) vol. 17:377-385.
Suhadolink, Robert J., et al., "Upregulation Of The 2-5A Synthetase/RNase L Antiviral Pathway Associated With Chronic Fatigue Syndrome," Clinical Infectious Diseases (1994) vol. 18, (Suppl 10:S96-S104.
Suhadolink, Robert J., et al., "Changes In The 2-5A Synthetase/RNase 1 Antiviral Pathway in A Controlled Clinical Trial With Poly(I)-Poly(C.sub.12 U) In Chronic Fatigue Syndrome," In Vivo (1994) vol. 8:599-604.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Methods and compositions for use in characterizing multiple scle does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for use in characterizing multiple scle, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for use in characterizing multiple scle will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1783071

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.