Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1999-04-27
2000-06-27
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 24, 435 23, 435 4, 435975, C12Q 142, C12Q 137, C12Q 100
Patent
active
060805544
ABSTRACT:
Methods are providing for characterizing multiple sclerosis disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have multiple sclerosis. The sample is then assayed for the presence of both high and low molecular proteins having RNAse L activity and a ratio of these two proteins is derived. The resultant ratio is then used to characterize the MS disease activity in the subject, e.g. to confirm an initial MS diagnosis, to determine the stage of the disease, to monitor disease progression, to predict disease attacks, and the like. Also provided by the subject invention are kits for practicing the methods.
REFERENCES:
patent: 5866119 (1999-02-01), Bandman et al.
Charachon, Guillaume, et al., "Phosphorothioate Analogues (2'-5')(A).sub.4 : Agonist And Antagonist Activities In Intact Cells," Biochemistry (1990) vol. 29:2550-2556.
Suhadolink, Robert J., et al., "Biochemical Evidence For A Novel Low Molecular Weight 2-5A-Dependent Rnase L In Chronic Fatigue Syndrome," Journal Of Interferon And Cytokine Research (1997) vol. 17:377-385.
Suhadolink, Robert J., et al., "Upregulation Of The 2-5A Synthetase/RNase L Antiviral Pathway Associated With Chronic Fatigue Syndrome," Clinical Infectious Diseases (1994) vol. 18, (Suppl 10:S96-S104.
Suhadolink, Robert J., et al., "Changes In The 2-5A Synthetase/RNase 1 Antiviral Pathway in A Controlled Clinical Trial With Poly(I)-Poly(C.sub.12 U) In Chronic Fatigue Syndrome," In Vivo (1994) vol. 8:599-604.
Campine Isabelle Willie Luce
De Meirleir Kenny Leo
Herst C. V. Taylor
Field Bret E.
Leary Louise N.
R.E.D. Laboratories N.V.
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