Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-11-28
2006-11-28
Zara, Jane (Department: 1635)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C435S091100, C435S458000
Reexamination Certificate
active
07141375
ABSTRACT:
A method is provided for treating solid tumors comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using the SELEX process for the Systematic Evolution of Ligands by Exponential enrichment. A method is also provided for reducing the interstitial fluid pressure (IFP) of a solid tumor comprising administering a PDGF aptamer. Finally, a method is provided for increasing the uptake of cytotoxic agents into a tumor comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent.
REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 5070010 (1991-12-01), Hsu
patent: 5270163 (1993-12-01), Gold et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5476766 (1995-12-01), Gold et al.
patent: 5502037 (1996-03-01), Kondra et al.
patent: 5595877 (1997-01-01), Gold et al.
patent: 5756291 (1998-05-01), Griffen et al.
patent: 6229002 (2001-05-01), Janjic et al.
patent: 2 183 661 (1987-06-01), None
patent: WO 89/06694 (1989-07-01), None
patent: WO 91/19813 (1991-12-01), None
patent: WO 92/05285 (1992-09-01), None
patent: WO 92/14843 (1992-09-01), None
Andrake et al. (1988)Proc. Natl. Acad. Sci. USA 85:7942-7946.
Bass and Cech (1984)Nature 308:820-826.
Betsholtz et al. (1984)Cell 39:447-457.
Bock et al. (1992)Nature 355:564-566.
Buchdunger et al. (1995)Proc. Natl. Acad. Sci. USA 92:2558-2562.
Carey et al. (1983)Biochemistry 22:2601-2610.
Cohen et al. (1969)Proc. Natl. Acad. Sci. USA. 63:458-464.
Duan et al. (1991)J. Biol. Chem. 266: 413-418.
Ellington and Szostak (1990) Cold Spring Harbor, NY p. 84.
Ellington and Szostak (1990)Nature 346:818-822.
Engstrom et al. (1992)J. Biol. Chem. 267:16581-16587.
Ferns et al.Science(1991) 253:1129-1132.
Floege et al. (1999) Am. J. Pathol. 154:169-179.
Green et al. (1996) Biochemistry 35:14413-14424.
Herren et al. (1993)Biochimica et Biophysica Acta 1173:294-302.
Jain (1996) Science 271:1079-1080.
Johnsson et al. (1985)Proc. Natl. Acad. Sci. USA 82:1721-1725.
Joyce (1989) Gene 82:83-87.
Joyce and Inoue (1989) Nucleic Acids Research 17:711-722.
Kacian et al. (1972)Proc. Natl. Acad. Sci. USA 69:3038-3042.
Kinzler and Vogelstein (1989) Nucleic Acids Research 17:3645-3653.
Kovalenko et al. (1994)Cancer Research, 54:6106-6114.
Kramer (1974) J. Mol. Biol. 89:719-736.
Kristjansen et al. (1993) Cancer Res. 53:4764-4766.
Kristensen et al. (1996) Br. J. Cancer 74:533-536.
Lee et al. (1992) Cancer Res. 52:3237-3240.
Lestienne et al. (1983)Biochime 65:49-52.
Levisohn and Spiegleman (1968)Proc. Natl. Acad. Sci.USA 60:866-872.
Levisohn and Spiegleman (1969)Proc. Natl. Acad. Sci.USA 63:805-811.
Ma and Ptashne (1987)Cell 51:113-119.
MacKeller et al. (1992)Nucleic Acids Research 20:3411-3417.
Maniatis et al. (1982)Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, NY., p. 118.
Maniatis et al. (1987)Science 236:1257-1245.
Matthews and Kricka (1988)Analytical Biochemistry 169:1-25.
Miele et al. (1983)J. Med. Biol. 171:281-295.
Mills et al. (1967) Proc. Natl. Acad. Sci. USA 58:217-220.
Mills et al. (1973)Science 180:916-927.
Min et al. (1988)Nucleic Acids Res. 16:5075-5088.
Muesing et al. (1985) Nature 313: 450-457.
Oliphant and Struhl (1987)Methods in Enzymology 155:568-582.
Oliphant and Struhl (1988)Nucleic Acids Research 16:7673-7683.
Oliphant et al. (1986)Gene 44:177-183.
Oliphant et al. (1989)Mol. Cell. Biol. 9:2944-2949.
Orgel (1979)Proc. R. Soc. Lond. B205:435-442.
Ou et al. (1988)Science 239:295-297.
Rich et al. (1984)Ann. Rev. Biochem. 53:791-846.
Robertson and Joyce (1990)Nature 344:467-468.
Romaniuk et al. (1987)Biochemistry 26:1563-1574.
Schimmel (1989)Cell 58:9-12.
Stein et al. (1993)Science 261:1004-1012.
Szostak (1988) (S.A. Benner ed.) Springer-Verlag Berlin Heidelberg, pp. 87-113.
Thiesen and Bach (1990)Nucleic Acids Res. 18:3203-3208.
Tiesman and Hart (1993)J. Biol. Chem. 268:9621-9628.
Tuerk and Gold (1990)Science 249:505-510.
Tuerk et al. (1988)Proc. Natl. Acad. Sci. USA 85:1364-1368.
Uhlenbeck et al. (1983)J. Biomolecular Structure and Dynamics 1:539-552.
Vassbotn et al. (1992)J. Biol. Chem. 267:15635-15641.
Vassbotn et al. (1994)J. Cell 'Physoil. 158:381-389.
Watson et al. (1987)Molecular Biology of the Gene, Benjamin/Cummings Publishing Co., Inc., CA., pp. 267, 295, 323, 361, 394, 396, 397, and 405.
Williams et al. (1984)J. Biol. Chem. 259:5287-5294.
Witherell and Uhlenbeck (1989)Biochemistry 28:71-76.
Yarus (1988)Science 240:1751-1758.
Uhrbom et al. (Feb. 2000)Int. J. Cancer 85:398-406.
Powis and Kozikowski (Oct. 1991)Clin Biochem. 24:385-397.
Pietras et al. (Apr. 2001) Cancer Research 61:2929-2934.
PUBMED Aids Alert (Jun. 1996) 11(6):67-68.
Saffhill et al. (1970)J. Mol. Biol. 51:531-539.
Heldin Carl-Henrik
Ostman Arne
Pietras Kristian
Rubin Kristofer
Gilead Sciences, Inc.
Swanson & Bratschun L.L.C.
Vivlemore Tracy
Zara Jane
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