Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-06-21
2011-06-21
Ton, Thaian N (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S325000, C536S023100
Reexamination Certificate
active
07964570
ABSTRACT:
The present invention provides methods and compositions for the treatment of diseases associated with aberrant microsatellite expansions. Methods of the present invention comprise the use of recombinant adeno-associated virus vectors containing a transgene encoding at least one muscleblind protein. The present invention also provides an animal model for a disease associated with aberrant microsatellite expansion.
REFERENCES:
Patil et al. The AAPS Journal, 7(1): Article 9, E61-E77, 2005.
Juengst et al. BMJ, 326: 1410-1411, Jun. 28, 2003.
Kay et al. Nature Med., 7(1): 33-40, Jan. 2001.
Trent. Chapter 6, Genetics and Cellular Therapies from Molecular Med: An Introductory Text, 2005, pp. 143-173.
Gregorevic. Expert. Opin. Biol. Ther., 3(5): 803-814, 2003.
Wikipedia. Trinucleotide repeat disorder, accesed online, May 5, 2009 at en.wikipedia.com.
Synder et al. Human Gene Therapy, 8: 1891-1900, Nov. 1997.
Uniprot website “MBNL1” accessed online on May 10, 2009.
Mankodi, et al., “Muscleblind Localizes to Nuclear Foci of Aberrant RNA in Myotonic Dystrophy Types 1 and 2”, Human Molecular Genetics, 2001, vol. 10, No. 19, 2165-2170.
Kanadia, et al., “A Muscleblind Knockout Model for Myotonic Dystrophy”, Science, 2003, vol. 302, 1978-1980.
Miller, et al., Recruitment of Human Muscleblind Proteins to (CUG)nExpansions Associated with Myotonic Dystrophy, The Embo Journal, 2000, vol. 19, No. 17 pp. 4439-4448.
Hartigan-O'Connor, et al., “Developments in Gene Therapy for Muscular Dystrophy”, Microscopy Research and Technique, 2000, 48:223-238.
International Search Report (Form PCT/ISA/220 (Jan. 2004).
Kanadia Rahul N.
Swanson Maurice S.
Thornton Charles A.
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Melissa Hunter-Ensor, Esq.
Ton Thaian N
University of Florida Research Foundation Inc.
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