Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1991-12-09
1993-09-28
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A61K 3170
Patent
active
052486710
ABSTRACT:
The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.
REFERENCES:
patent: 4107937 (1978-08-01), Chmiel
patent: 4481946 (1984-11-01), Altshuler et al.
patent: 4486188 (1984-12-01), Altshuler et al.
patent: 4511713 (1985-04-01), Miller
patent: 4721096 (1988-01-01), Naughton et al.
patent: 4740463 (1988-04-01), Weinberg et al.
patent: 4757055 (1988-07-01), Miller
patent: 5023243 (1991-06-01), Tullis
patent: 5098890 (1992-03-01), Gewirtz et al.
Munroe, et al., "Loss of highly conserved domain on p53 as a result of gene deletion during Friend virus-induced erythroleukemia" Oncogene 2:621-624 (1988).
David, et al., "Inactivation of the p53 oncogene by internal deletion or retroviral integration in erythroleukemic cell lines induced by Friend leukemia virus" Oncogene 3:179-185 (1988).
Matsukura, et al., "Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV)" Gene 72:343-347 (1988).
Levi and Ozato, "Constitutive expression of c-fos antisense RNA blocks c-fos gene induction by interferon and by phorbol ester and reducec c-myc expression in F9 embryonal carcinoma cells" Genes and Development 2:554-566 (1988).
Stein and Cohen, "Oligodeoxynucleotides as Inhibitors of Gene Expression: A Review" Cancer Research 48:2659-2668 (May 15, 1988).
Matsukura, et al., "Phosphorothioate analogs of oligodeoxynucleotides: Inhibitors of replication and cytopathic effects of human immunodeficiency virus" Proc. Natl. Acad. Sci. USA 84:7706-7710 (Nov. 1987).
Lubbert, et al., "p53 In Chronic Myelogenous Leukemia, Study of Mechanisms of Differential Expression" J. Exp. Med. 167:873-886 (Mar. 1988).
Paoletti, "Anti-sense oligonucleotides as potential antitumour agents: prospective views and preliminary results" Anti-Cancer Drug Design 2:325-331 (1988).
Cattoretti, et al., "Vimentin and p53 expression on epidermal growth factor receptor-positive, oestrogen receptor-negative breast carcinomas" Br. J. Cancer 57:353-357 (1988).
Yokoyama, et al., "Transcriptional control of the endogenous antisense RNA" Proc. Natl. Acad. Sci. USA 84:7363-7367 (Nov. 1987).
Mercola, et al., "Antisense RNA To The C-FOS Gene: Restoration of Density Dependent Growth Arrest In A Transformed Cell Line" Biochemical and Biophysical Research Communications 147(1), 288-294 (Aug. 31, 1987).
Nishikura and Murray, "Antisense RNA of Proto-Oncogene c-fos Blocks Renewed Growth of Quiescent 3T3 Cells" Molecular and Cellular Biology 7(2), 639-649 (Feb. 1987).
Shohat, et al., "Inhibition of cell growth mediated by plasmids encoding p53 anti-sense" Oncogene 1:277-283 (1987).
Boyle and Gee, "Low Antigen Density Tumor Cells: An Obstacle to Effective Autologous Bone Marrow Purging?" Cancer Investigation 5(2), 113-118 (1987).
Rovinski et al., "Deletion of 5'-Coding Sequences of the Cellular p53 Gene in Mouse Erythroleukemia: A Novel Mechanism of Oncogene Regulation" Molecular and Cellular Biology 7(2), 847-853 (Feb. 1987).
Kopelovich and DeLeo, "Elevated Levels of p53 Antigen in Cultured Skin Fibroblasts From Patients With Hereditary Adenocarcinoma of the Colon and Rectum and its Relevance to Oncogenic Mechanisms" JNCI 77(6), 1241 (Dec. 6, 1986).
Holt et al., "Inducible Production of C-fos Antisense Cell Proliferation" Proc. Natl. Acad. Sci. 83:4794-4798 (1986).
Lamb and Crawford, "Characterization of the Human p53 Gene" Molecular and Cellular Biology 6:1379-1385 (May 1986).
LaPlanche, et al., "Phosphorothioate-modified oligodeoxyribonucleotides. III. NMR and UV spectroscopic the R.sub.p -R.sub.p, S.sub.p -S.sub.p, and R.sub.p -S.sub.p duplexes, [d(GG.sub.s AATTCC)].sub.2, derived from diasteromeric phosphorothioates" Nucleic Acids Research 13(22), 9081-9093 (Nov. 1986).
Smith, et al., "Expression of the p53 Oncogene Acute Myeloblastic LP" J. Exp. Med. 164:751-761 (Sep. 1986).
Kaczmarek et al., "Co-operation between the p53 Protein Tumor Antigen and Platelet-poor Plasma in the Induction of Cellular DNA Synthesis" Exp. Cell Res. 162:268-272 (1986).
Nara and McCulloch, "A Comparison of The Growth Supporting Capacities of Fresh and Cultured Leukemic Blast Cells" Leukemia Research 10(3), 273-277 (1986).
Prokocimer, et al., "Expression of p53 in Human Leukemia and Lymphoma" Blood 68(1), 113-118 (Jul. 1986).
Kim and Wold, "Stable Reduction of Thymidine Kinase Activity in Cells Expressing High Levels of Anti-Sense RNA" Cell, 42:129-138 (Aug. 1985).
Eliyahu, et al., "Overproduction of p53 antigen makes established cells highly tumorigenic" Nature 316:158-160 (Jul. 11, 1985).
Mowat, et al., "Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus" Nature 314:633-636 (Apr. 18, 1985).
Izant and Weintraub, "Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA" Science 229:345-452 (Jul. 26, 1985).
Parada, et al., "Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation" Nature 312:649-651 (Dec. 13, 1984).
Izant and Weintraub, "Inhibition of Thymidine Kinase Gene Expression by Anti-Sense RNA: A Molecular Approach to Genetic Analysis" Cell 36:1007-1015 (1984).
Mercer, et al., "Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies" Molecular and Cellular Biology 4(2), 276-181 (Feb. 1984).
McCulloch, et al., "Heterogenity in Acute Myeloblastic Leukemia" Leukemia, vol. 2:12 (date of publication unknown).
Curtis, et al., "Contributions of Host- and Disease-Related Attributes to the Outcome of Patients with Acute Myelogenous Leukemia" J. Clinical Oncology 2(4), 253-259 (Apr. 1984).
McCulloch, et al., "The Contribution of Blast Cell Properties to Outcome Variation in Acute Myeloblastic Leukemia (AML)" Blood 59(3), 601-608 (Mar. 1982).
Mercer, et al., "Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells" Proc. Natl. Acad. Sci. 79:6309-6312 (Oct. 1982).
Chang, et al., "Reconstitution of haemopoietic system with autologous marrow taken during relapse of acute myeloblastic leukaemia and grown in long-term culture" Lancet, Feb. 8, 1986:294-295.
Harlow, et al., "Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53" Chemical Abstracts, vol. 103, No. 11, Sep. 16, 1985, Abstract 82693K.
Wickstrom, et al., "Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA" Chemical Abstracts, vol. 108, No 21, May, 23, 1988; and Proc. Natl. Acad. Sci. 85:1028-32 (Feb. 1988).
Heikkila, et al., "A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G.sub.0 to G.sub.1 " Nature 328:445-449 (Jul. 30, 1987).
Matlashewski, et al., "Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene" EMBO Journal 3(13), 3257-3262 (1984).
Dippold, et al., "p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells" Proc. Natl. Sci. USA 78(3), 1695-1699 (Mar. 1981).
Dialog Search.
Gewirtz, Alan M. and Calabretta, Bruno, "A c-myb Antisense Oligodeoxynucleotide Inhibits Normal Human Hematopoiesis in Vitro" Science 242:1303-1306 (Dec. 2, 1988).
Salikumar et al., "Role of tryptophan repeats and flanking amino acids in Myb-DNA interactions" Proc. Natl. Acad. Sci. USA 87:8452-8456 (Nov. 1990).
Calabretta et al., "Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: An in vitro study relevant to bone marrow purging" Proc. Natl. Acad. Sci. USA 88:2351-2355 (Mar. 1991).
Konopka and Witte, "Act
Board of Regents , The University of Texas System
Rollins John W.
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