Methods and compositions for treatment of cancer using oligonucl

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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A61K 3170

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050876171

ABSTRACT:
The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.

REFERENCES:
patent: 4107937 (1978-08-01), Chmiel
patent: 4481946 (1984-11-01), Altshuler et al.
patent: 4486188 (1984-12-01), Altshuler et al.
Chang et al., Lancet, Feb. 8, 1986:294-295.
Dippold et al., Proc. Natl. Sci. USA 78:1695-1699 (1981).
Heikkliala et al., Nature 328:445-449 (1987).
Matlashewski et al., Embo Journal 3:3257-3262.
Chemical Abstracts, vol. 103, No. 11, 16 Sep. 1985, E. Harlow et al., Abstract 82693K.
Chemical Abstracts, vol. 108, No. 21, 23 May 1988, Wickstrom et al.
Proc. Natl. Acad. Sci. 84:1028-32 (1988), Wickstrom et al.
Munroe et al., Oncogene 2:621-624 (1988).
David et al., Oncogene 3:179-185 (1988).
Matsukura et al., Gene 72:343-347 (1988).
Levi and Ozato, Genes and Development 2:554-566 (1988).
Stein and Cohen, Cancer Research 48:2659-2668 (1988).
Matsukura et al., Proc. Natl. Acad. Sci. 84:7706-7710 (1987).
Lubbert et al., J. Med. 167:873-886 (1988).
Paoletti, Anti-Cancer Drug Design 2:325-331 (1988).
Cattoretti et al., British Journal of Cancer 57:353-357 (1988).
Yokoyama et al., Proc. Natl. Acad. Sci. USA 84:7363-7367 (1987).
Mercola et al., Biochemical and Biophysical Research Communications 147:288-294 (1987).
Nishikura and Murray, Molecular and Cellular Biology, 7:639-649 (1987).
Shohat et al., Oncogene 1:277-283 (1987).
Boyle and Gee, Cancer Investigation 5:113-118 (1987).
Rovinski et al., Molecular and Cellular Biology 7:847-853.
Kopelovich and Deleo, JNCL 77:1241 (1986).
Holt et al., Prop. Natl. Acad. Sci. 83:4794-4798 (1986).
Lamb and Crawford, Molecular and Cellular Biology, 6:1379-1385 (1986).
LaPlanche et al., Nucleic Acids Research 13:9081-9093 (1986).
Smith et al., J. Exp. Med. 164:751-761 (1986).
Kaczmarek et al., Exp. Cell Res. 162:268-272 (1986).
Nara and McCulloch, Leukemia Research 10:273-277 (1986).
Prokocimer et al., Blood 68:113-118 (1986).
Kim and Wold, Cell, 42:129-138 (1985).
Eliyahu et al., Nature 316:158-160 (1985).
Mowat et al., Nature 314:633-636 (1985).
Izant and Weintraub, Science 229:345-452 (1985).
Parada et al., Nature 312:649-651 (1984).
Izant and Weintraub, Cell, 36:1007-1015 (1984).
Mercer et al., Molecular and Cellular Biology 4:276-181 (1984).
McCulloch et al., Leukemia, vol. 2:12 (date of publ. unknown).
Curtis et al., J. Clinical Oncology 2:253-259 (1984).
McCulloch et al., Blood 59:601-608 (1982).
Mercer et al., Proc. Natl. Acad. Sci. 79:6309-6312 (1982).
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