Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Patent
1995-05-31
1998-09-01
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
4241841, 4241851, 530380, 435 694, A61K 3818
Patent
active
058008209
ABSTRACT:
The subject invention pertains to compositions and methods of treatment of angiogenesis using PF4 and peptide fragments thereof.
REFERENCES:
patent: 4645828 (1987-02-01), Twardzik et al.
patent: 4737580 (1988-04-01), Twardzik et al.
patent: 5086164 (1992-02-01), Maione et al.
patent: 5112946 (1992-05-01), Maione
patent: 5248666 (1993-09-01), Twardzik et al.
patent: 5284827 (1994-02-01), Maione et al.
Folkman, J. et al. (1983) "The role of heparin in angiogenesis" Ciba Found. Symp. 100:132-149.
Folkman, J., M. Klagsbrun (1987) "Angiogenic Factors" Science 235:442-447.
Folkman, J. (1984) "Angiogenesis: Initiation and Modulation" in Cancer Invasion and Metastasis: Biologic and Therapeutic Aspects 201-208.
Taylor, S., J. Folkman (1982) "Protamine is an inhibitor of angiogenesis" Nature 297:307-312.
Deuel, T.F. et al. (1981) "Platelet factor 4 is chemotactic for neutrophils and monocytes" Proc. Natl. Acad. Sci. USA 78(7):4585-4587.
Osterman, D.G. et al. (1982) "The carboxyl-terminal tridecapeptide of platelet factor 4 is a potent chemotactic agent for monocytes" Biochem. and Biophys. Res. Comm. 107(1):130-135.
Wolpe, S.D., A. Cerami (1989) "Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines" FASEB Journal 3:2565-2573.
Cotran, R.S. et al. (1989) "Female Genital Tract" Robbins Pathologic Vasis of Disease, 4 Edition, pp. 1146-1159.
Maione, T.E. et al. (1991) "Inhibition of Tumor Growth in Mice by an Analogue of Platelet Factor 4 That Lacks Affinity for Heparin and Retains Potent Angiostatic Activity" Cancer Research 51:2077-2083.
Cunningham Thomas M.
Repligen Corporation
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