Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-04-18
1987-05-05
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514356, 514523, 514929, 514934, A61K 3155, A61K 3144, A61K 31275
Patent
active
046633170
ABSTRACT:
The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents. These two subclasses are characterized mechanistically as calcium influx blockers (or calcium channel blockers) and cyclic nucleotide modulators. More specifically, the class of calcium influx blockers is exemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototype drug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators is exemplified by the drugs isobutylmethylxanthine, papaverine (and its synthetic analog dioxyline), forskolin, and sodium nitroprusside. All of these agents inhibit replication of HCMV and HSV.
REFERENCES:
Albrecht, T. et al. (1984) "Cellular Responses to Human Cytomegalovirus Infection" in CMV: Pathogenesis and Prevention of Human Infection, Birth Defects: Original Article Series, vol. 20, No. 1.
Albrecht, T., Speelman, D. J. and Steinsland, O. S. (1983) Life Sciences, 32:2273.
Albrecht, T., Speelman, D. J. Nokta, M., and Steinsland, O. S. (1984) "Control of Cytomegalovirus Expression and Replication by Modification of the Cellular Response to Virus Infection"(Abstract).
Stanwick, et al., (1977), Infect. Immun. 18:342-347.
Lucas, et al. (1978), J. Exp. Med., 148:940-952.
Robbins, et al. (1980), Virology, 106:317-326.
Miller, et al. (1982), Proc. Natl. Acad. Sci., 79:1629-1633.
Albrecht Thomas
Steinsland Odd S.
Board of Regents University of Texas System
Brown Johnnie R.
Rollins John W.
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