Methods and compositions for treating viral infections

Details Methods and compositions for treating viral infections Methods and compositions for treating viral infections

1986-06-05

1989-01-24

Rollins, John

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

514211, 514263, 514307, 514356, 514455, 514523, 514 2, A61K 3300, A61K 3155, A61K 3152, A61K 3147

Patent

active

048000817

ABSTRACT:
The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents alone or in combination with each other. These two subclasses are characterized mechanistically as calcium influx blockers (or calcium channel blockers) and cyclic nucleotide modulators. More specifically, the class of calcium influx blockers is exemplified by the drugs verapamil (and methoxyverapamil), nifedipine (the prototype drug of 1,4 dihydropyridines), and diltiazem. The class of cyclic nucleotide modulators is exemplified by the drugs isobutylmethlyxanthine, papaverine (and its synthetic analog dioxyline), forskolin, and sodium nitroprusside. In addition, the present disclosure demonstrates that agents from one class, e.g., a calcium influx blocker, act synergistically when used in combination with agents from the other class, e.g., cyclic nucleotide modulators. Moreover, the calcium influx blockers are shown to act synergistically when used in combination with alpha interferon.

REFERENCES:
patent: 4663317 (1987-05-01), Albrecht et al.
International Search Report.
Albrecht, T. et al., (1984), "Cellular Responses to Human Cytomegalovirus Infection" in CMV; Pathogenesis and Prevention of Human Infection, Birth Defects: Original Article Series, vol. 20, No. 1.
Albrecht, T., Speelman, D. J. and Steinsland, O. S., (1983), Life Sciences, 32:2273.
Albrecht, T., Speelman, D. J., Nokta, M. and Steinsland, O. S., (1984), "Control of Cytomegalovirus Expression and Replication by Modification of the Cellular Response to Virus Infection" (Abstract).
Stanwick, et al. (1977), Infect. Immun. 18:342-347.
Lucas, et al. (1978), J. Exp. Med., 148:940-952.
Robbins, et al. (1980), Virology, 106:317-326.
Miller, et al. (1982), Proc. Natl. Acad. Sci., 79:1629-1633.
Grunberg, et al. (1970), Ann. N.Y. Acad. Sci., 173:122.
Tampieri, et al. (1980), Med. Biol. Environ., 8:199.
Tampieri, et al. (1981), Ann. Sclavo, 23:214.
Yoshikawa, et al., (1984), Jrnl. Virol., 50:489.
Nugent, et al. (1984), Arch. Virol., 81:163.
Dialog Search Report.
Albrecht et al. (1985), 10th Intl. Herpes Virus Workshop, Ann Arbor, pp. 58-59.

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