Methods and compositions for treating rheumatoid arthritis

Details Methods and compositions for treating rheumatoid arthritis Methods and compositions for treating rheumatoid arthritis

1997-10-06

2000-01-18

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, A61K 3800

Patent

active

060157909

ABSTRACT:
The present invention provides compositions and methods for the treatment of rheumatoid arthritis in a subject wherein one or more compounds of Formula I as defined herein alone or in combination with one or more other antiarthritic drugs provide suppression of rheumatoid arthritis.

REFERENCES:
patent: 4816444 (1989-03-01), Pettit et al.
patent: 5502032 (1996-03-01), Haupt et al.
patent: 5504191 (1996-04-01), Pettit et al.
patent: 5530097 (1996-06-01), Pettit et al.
patent: 5583153 (1996-12-01), Brahn
Massarotti, E.M., "Medical Aspects of Rheumatoid Arthritis: Diagnosis and Treatment," Oncology, 12(3):463-475(1996).
Harris, E.D., "Rheumatoid Arthritis: Pathophysiology and Implications for Therapy," N. Engl. J. Med., 332(18):1277-1289(1990).
Beckwith, M., et al., "Growth Inhibition of Human Lymphoma Cell Lines by the Marine Products, Dolastatins 10 and 15," J. Natl. Cancer Inst., 85(6):483-488(1993).
Galeotti, N., et al., "Formation of Oxazolines and Thiazolines in Peptides by the Mitsunobu Reaction," Tetrahedron Letters, 33(20):2807-2810(1992).
Wipf, P., and Miller, C.P., "A Short, Stereospecific Synthesis of Dihydrooxazoles from Serine and Threonine Derivatives," Tetrahedron Letters, 33(7):907-910(1992).
Tully, W.R., et al., "2-(Oxadiazolyl)- and 2-(Thiazolyl)imidazo[1,2-a]pyrimidines as Agonists and Inverse Agonists at Benzodiazepine Receptors," J. Med. Chem., 34:2060-2067(1991).
Freidinger, R.M., et al., "Protected Lactam-Bridged Dipeptides for Use as Conformational Constraints in Peptides," J. Org. Chem., 47:104-109(1982).
Pettit, G.R., et al., "Isolation and Structure of the Cytostatic Linear Depsipeptide Dolastatin 15.sup.1a," J. Org. Chem., 54:6005-6006(1989).
Bai, R., et al., "Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects on cellular microtubules," Biochem. Pharmacol. 43(12):2637-2645(1992). (Abstract 117:103735g from 1-Pharmacology, p. 41, 1992).
Pettit, G.R., et al., "Antineoplastic Agents. 220. Synthesis of Natural (-)-Dolastatin 15.sup.1," J. Am. Chem. Soc., 113:6693-6695(1991).
Banerjee, S., et al., "Influence of Complement C5 and V.sub..beta. T Cell Receptor Mutations on Susceptibility to Collagen-Induced Arthritis in Mice.sup.1," J. Immunol, 142(7):2237-2243(1989).

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