Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Reexamination Certificate
2008-03-13
2011-11-22
Haghighatian, Mina (Department: 1616)
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
C424S046000, C424S489000, C424S400000, C424S443000, C424S451000, C514S826000
Reexamination Certificate
active
08062627
ABSTRACT:
A method and composition are disclosed utilizing the pure (R,R) isomer of formoterol, which is a potent bronchodilator with reduced adverse effects, a low incidence of the development of tolerance and an increased duration of action, as compared to racemic formoterol.
REFERENCES:
patent: 3994974 (1976-11-01), Murakami et al.
patent: 4380534 (1983-04-01), Fukui
patent: 4814161 (1989-03-01), Jinks
patent: 4917676 (1990-04-01), Heiber
patent: 4975466 (1990-12-01), Bottcher et al.
patent: 5135954 (1992-08-01), McDonald
patent: 5362755 (1994-11-01), Barberich et al.
patent: 5795564 (1998-08-01), Aberg et al.
patent: 6068833 (2000-05-01), Aberg et al.
patent: 6299863 (2001-10-01), Aberg et al.
patent: 6589508 (2003-07-01), Aberg et al.
patent: 6866839 (2005-03-01), Aberg et al.
patent: 7368120 (2008-05-01), Aberg et al.
patent: 2255503 (1992-11-01), None
patent: WO92/05147 (1992-04-01), None
“Racemic Therapeutics-ethical and Regulatory Aspects” Ariens Eur. J. Clin. Pharmacol 41, 89-93 (1991).
“Stereoselectiyity in Pharmacodynamics and Pharmacokinetics” Ariens Schjweiz. Med. Wochenschr. 120, 131-134 (1990).
“Racemates Versus Enantiomers in Drug Development: Dogmatism or Pragmatism” Testa et al. Chirality 2, 129-133 (1990).
Beta-Adrenoceptor Ligands: Characterization and Quantification of Drug Effects Lemoine Quant. Struct.-Act. Relat. 11, 211-218 (1992).
“Absolute Configurations of Four Isomers of 3-Formamido-4-hydroxy-beta-[[N-(-p-methoxy-alpha-methylphenethyl) amino]methyl]benyl Alcohol, a Potent Beta-Adrenoreceptor Stimulant,” Murase et al. Chem. Pharm. Bull. 26, 1123-29 (1978).
“A Three-Month Comparison of Twice Daily Inhaled Formoterol Versus Four Times Daily Inhaled Albuterol in the Management of Stable Asthma”, Keston et al. Am. Rev. Respir. Dis. 144 622-625 (1991).
“Steric Aspects of Agonism and Antagonism at Beta-Adrenoceptors: Synthesis of and Pharmacological Experiments With the Enantiomers of Formoterol and their Diasteromers” Trofast et al. Chirality 3 443-450 (1991).
“New Beta-Adrenoreceptor Stimulants. Studies on 3-Acylamino-4-hydroxy-alpha-(N-substituted aminomethyl) benzyl Alcohols” Murase et al. Chem. Pharm. Bull. 25(6) 1368-1377 (1977).
“Cardiorespiratory Activities of 3-Formylamino-4-hydroxy alpha-(n-1-methyl-2-methoxyphenethylaminomethyl)-benzylalcohol-bemifumarate (BD 40A) and some other Beta-Adrenoceptor Stimulants in Conscious Guinea Pigs” H. Ida Arzneim.-Forsch. 26, 1337-1340 (1976).
“Comparison of the Action of BD 40 A and some other Beta-Adrenoceptor Stimulants of the Isolated Trachea and Atria of the Guinea Pig” H. Ida Arzneim.Forsch. 26, 839-842 (1976).
The Merck Index. S. Budavari. Ed. 11th edition. pp. 4159-4160. 1989.
Hett et al, Enantio- and Diastereoselective Synthesis of all Four Steroisomers of Formoterol, Tet. Lett. 38, 1125-1128 (1997).
International Search Report for international application PCT/US93/07397 (1993).
Machine Translation by Google translate of E. J. Ariens. “Racemische therapeutica probleemmiddelen”, Pharmaceutish Weekblad, 125, 552-554 (1990).
Aberg Gunnar
Morley John
Haghighatian Mina
Heslin Rothenberg Farley & & Mesiti P.C.
Sunovion Pharmaceuticals Inc.
LandOfFree
Methods and compositions for treating pulmonary disorders... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for treating pulmonary disorders..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for treating pulmonary disorders... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4276542