Methods and compositions for treating male erectile dysfunction

Details Methods and compositions for treating male erectile dysfunction Methods and compositions for treating male erectile dysfunction

2007-09-04

2007-09-04

Nickol, Gary B. (Department: 1647)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C424S198100

Reexamination Certificate

active

11040947

ABSTRACT:
The invention provides a method for preventing or treating male erectile dysfunction or female sexual arousal disorder by administering an effective amount of one or more factors from a group of factors including vascular endothelial growth factor, brain-derived neurotrophic factor, basic fibroblast growth factor, neurotrophin-3, neurotrophin-4, or angiopoietin-1, wherein the factor is a full length protein or a nucleic acid encoding the factor, or a functional derivative or fragment thereof, or an agent that enhances production and/or male erection or female sexual arousal stimulating function of the factor(s). Combinations, kits, and combinatorial methods are also provided.

REFERENCES:
patent: 5026839 (1991-06-01), Moscatelli
patent: 5130418 (1992-07-01), Thompson
patent: 5155214 (1992-10-01), Baird
patent: 5180820 (1993-01-01), Yancopoulos
patent: 5188943 (1993-02-01), Florkiewicz
patent: 5217954 (1993-06-01), Foster
patent: 5229500 (1993-07-01), Barde
patent: 5235043 (1993-08-01), Collins
patent: 5270053 (1993-12-01), Schneider
patent: 5387673 (1995-02-01), Seddon
patent: 5438121 (1995-08-01), Barde
patent: 5552157 (1996-09-01), Yagi
patent: 5589377 (1996-12-01), Lebkowski
patent: 5607918 (1997-03-01), Eriksson
patent: 5646181 (1997-07-01), Fung
patent: 5662931 (1997-09-01), Munechika
patent: 5686102 (1997-11-01), Gross
patent: 5693531 (1997-12-01), Chiorini
patent: 5736154 (1998-04-01), Fuisz
patent: 5741511 (1998-04-01), Lee
patent: 5753500 (1998-05-01), Shenk
patent: 5770228 (1998-06-01), Edwards et al.
patent: 5770606 (1998-06-01), El-Rashidy et al.
patent: 5830725 (1998-11-01), Nolan
patent: 5886039 (1999-03-01), Kock
patent: 5891915 (1999-04-01), Wysor
patent: 5939096 (1999-08-01), Clerc
patent: 5941868 (1999-08-01), Kaplan
patent: 5942545 (1999-08-01), Samour
patent: 5945117 (1999-08-01), El-Rashidy
patent: 5981225 (1999-11-01), Kochanek
patent: 5986070 (1999-11-01), Collins
patent: 5994128 (1999-11-01), Fallaux
patent: 6007838 (1999-12-01), Alving
patent: 6031002 (2000-02-01), Wysor
patent: 6037320 (2000-03-01), Rosenthal
patent: 6056966 (2000-05-01), Selim
patent: 6063622 (2000-05-01), Chamberlain
patent: 6077829 (2000-06-01), Tanaka
patent: 6083750 (2000-07-01), Chamberlain
patent: 6120798 (2000-09-01), Allen
patent: 6133026 (2000-10-01), Huang
patent: 6197801 (2001-02-01), Lin
patent: 6193992 (2001-03-01), El-Rashidy
patent: 6197333 (2001-03-01), Onyuksel
patent: 6221646 (2001-04-01), Dwarki
patent: 6251871 (2001-06-01), Jin
patent: 6258374 (2001-07-01), Friess
patent: 6436944 (2002-08-01), Maytom
patent: 2002/0032153 (2002-03-01), Whitehouse
patent: WO-00/43029 (2000-07-01), None
patent: WO 0072871 (2000-12-01), None
patent: WO-01/24809 (2001-04-01), None
patent: WO-01/68125 (2001-09-01), None
Purves et al., NEUROSCIENCE, 2nd Edition, 2001, Sinauer Associates, Inc.
Achen et al., Proc. Nat'l. Acad. Sci. USA, 95(2):548-553 (1998).
Alm et al., Acta Physiol. Scand. 148:421 (1993).
Anthony et al., Placenta, 15:557 (1994).
Asahara et al., Circulation, 91(11):2793-801 (1995).
Azadzoi and Saenz de Tejada, Journal of Urology, 146(1):238-40 (1991).
Baffour et al., J. Vasc. Surg., 16:181 (1992).
Bakircioglu et al., Journal of Urology, 163(4):198 (2000).
Banai et al., Circulation, 89(5):2183-9 (1994).
Baumgartner et al., Circulation, 97(12):1114-23 (1998).
Bauters et al., Am. J. Physiol., 267(4 Pt 2):H1263-71 (1994).
Bauters et al., Circulation, 91(11):2802-9 (1995).
Brown et al., Lab. Invest., 76:245 (1997).
Burchardt et al., Biol. Reprod., 60(2):398 (1999).
Burchardt et al., IUBMB Life, 48:405 (1999).
Carrier et al., J. Urol., 153:1722 (1995).
Cheung et al., Am. J. Obstet. Gynecol., 173:753 (1995).
Christ, Urol. Clin. North Am., 22:727 (1995).
Claffey et al., J. Biol. Chem., 267:16317 (1992).
Couper et al., Circ. Res., 81:932 (1997).
D'Amore et al., Ann. Rev. Physiol., 49(9-10):453-64 (1987).
Distefano et al., Neuron, 8:983 (1992).
Dong et al., Hum. Gene Ther., 7:2101 (1996).
During and Leone, Clin. Neurosci., 3:292 (1995).
Dvorak et al., Current Topics in Microbiology and Immunology, 237(1):97-132 (1999).
El-Sakka et al., J. Urol., 160:2245 (1998).
Ferrara, Breast Cancer Research and Treatment, 36(2):127-37 (1995).
Ferrara et al., Endocr. Rev., 13:18 (1992).
Folkman et al., Proc. Nat'l. Acad. Sci., 76(10):5217-21 (1979).
Folkman and Shing, Journal of Biological Chemistry, 267(16):10931-4 (1992).
Franck-Lissbrant et al., Endocrinology, 139:451 (1998).
Garban et al., Biol. Reprod., 53:1365 (1995).
Gimenez et al., J. Neurosci. Res., 48:281 (1997).
Goldberg et al., J. Biol. Chem., 269:4355 (1994).
Goldstein et al., JAMA, 251(7):903-910 (1984).
Goldstein, International Journal of Impotence Research (2000) 12(4):S152-157.
Goodman & Gilman, Pharmacological Basis Of Therapeutics, 9th ed., McGraw-Hill Press (1996), pp. 77-101.
Gross et al., Proc. Nat'l. Acad. Sci., 80(9):2623-27 (1983).
Grosskreutz et al., Microvasc. Res., 58:128 (1999).
Haggstrom et al., Prostate, 36:71 (1998).
Haggstrom et al., J. Urol., 161:1620 (1999).
Harada et al., American Journal of Physiology, 270(5 Pt 2):H1791-802 (1996).
Hariawala et al., J. Surg. Res., 63(1):77-82 (1996).
Hatzichristou et al., J. Urol., 153:1126 (1995).
Heaton et al., Int'l J. Impotence Res., 8(1):35-39 (1996).
Hopkins et al., J. Vascular Surgery, 27(5):886-94 (1998).
Houck et al., J. Biol. Chem., 267(36):26031-7 (1992).
Ide, Neurosci. Res., 25:101 (1996).
Jin et al., Proc Natl Acad Sci USA, 97:10242-7(2000).
Jingjing et al., Ophthamol. Vis. Sci., 40:752 (1999).
Joukov et al., EMBO J., 15:1571 (1996).
Joukov et al., EMBO J., 15(2):290-298 (1996).
Jung et al., J. Urol., 160:1899 (1998).
Jung et al., Int. J. Impotence Res., 11:247 (1999).
Karadeniz et al., Urol. Int., 55:143 (1995).
Karadeniz et al., Urol. Int., 57:85 (1996).
Kawasuji et al., Ann. Thorac. Surg., 69:1155 (2000).
Kim et al., Journal of Urology, 151(1):198-205 (1994).
Kornowski et al., Circulation, 101:545-48 (2000).
Korsching, J. Neurosci., 13:2739 (1993).
Laham et al., J. Am. Coll. Cardiol., 36:2132-39 (2000).
Laham et al., Curr. Interv. Cardiol. Rep., 1:228 (1999).
Lazarous et al., J. Am. Coll. Cardiol., 36:1239 (2000).
Lee et al., J. Urol., 163(4):198 (2000).
Lei et al., Biochim. Biophys. Acta, 1443:400 (1998).
Leibrock et al., Nature, 341:149 (1989).
Lekas et al., Urol. Res., 25:309 (1997).
Leung et al., Science, 246:1306-09 (1989).
Levine et al., J. Urology, 144(5):1147-53 (1990).
Lewin and Barde, Ann. Rev. Neurosci., 19:289 (1996).
Lin et al., PNAS USA, 97:10242-47 (2000).
Liu et al., J. Urol., 166:354-360 (2001).
Losordo et al., Am. Heart J., 138(2 Pt 2):132-41 (1999).
Lue et al., New England J. Med., 342(24):1802-1813 (2000).
Maeda et al., Cardiovasc. Res., 35:514 (1997).
Maglione et al., Oncogene, 8:925 (1993).
Magovern et al., Human Gene Therapy, 8(2):215-27 (1997).
Mannino and Gould-Fogerite, Bio Techniques, 6:682 (1988).
Matsushita et al., Gene Ther. 5:938 (1998).
McLaughlin et al., J. Virol. 62:1963 (1988).
Meisel et al., Horm. Behav., 18:56 (1984).
Mersdorf et al., J. Urol., 154:749 (1991).
Meyer et al., J. Cell Biol., 119:45 (1992).
Miller et al., Blood, 82:1900 (1993).
Mills et al., Biol. Reprod., 51:234 (1994).
Mills et al., Biol. Reprod., 59:1413 (1998).
Mills et al., Steroids, 64:605 (1999).
Nehra et al., J. Urol., 156:1320 (1996).
Neufeld et al., FASEB J., 13(1):9-22 (1999).
Nonomura et al., Brain Res., 683:129 (1995).
Ohara et al., Gene Ther., 8:837 (2001).
Olofsson et al., PNAS USA, 93:2576 (1996).
Oppenheim et al., Nature, 360:755 (1992).
Ortega et al., Front. Biosci., 4(4):D141-152 (1999).
Paick et al., Urology, 42:145 (1993).
Park et al., Int'l J. Impotence Res., 9(1):27-37 (1997).
Parker et al., J. Steroid Biochem., 6:1 (1975).
Podsakoff et al., J. Virol., 68:5656 (1994).
Poltorak et al., J. Biol. Chem., 272(11):7151-78 (1997).
Pueyo et al., Exp. Cell Res., 238:354 (1998).
Quantin et al., PNAS USA, 89:2581-2584 (1992).
Rajanayagam et al., J. Am. Coll. Cardiol., 35:519 (2000).
Rakue et al., Japan Circ. J., 62:933-39 (1998).
Rosen et al., Radiology, 174(3 Pt 2):1043-48 (1990).
Rosenfeld et al., Cell, 68:143-155 (1992).
Shweiki et al., PNAS U

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