Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2009-07-17
2010-10-19
Haddad, Maher M (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C424S144100, C424S133100, C530S388220
Reexamination Certificate
active
07815908
ABSTRACT:
The present invention provides compositions and methods for treating and preventing disease associated with αvβ5 integrin by blocking binding to αvβ5 integrin.
REFERENCES:
patent: 5519138 (1996-05-01), Ries et al.
patent: 5527679 (1996-06-01), Hemler et al.
patent: 5780426 (1998-07-01), Palladino et al.
patent: 6069158 (2000-05-01), Miller et al.
patent: 6291196 (2001-09-01), Vielkind
patent: 6683051 (2004-01-01), Jonczyk et al.
patent: 6692741 (2004-02-01), Huang et al.
patent: 7053041 (2006-05-01), Brooks et al.
patent: 2002/0037889 (2002-03-01), Duggan et al.
patent: 2002/0072500 (2002-06-01), Rogers et al.
patent: 2002/0077321 (2002-06-01), Khanna et al.
patent: 2003/0139398 (2003-07-01), Hoekstra et al.
patent: 2003/0171271 (2003-09-01), Baciu et al.
patent: 2003/0181440 (2003-09-01), Costanzo et al.
patent: 2004/0010023 (2004-01-01), Stahle et al.
patent: 2004/0018192 (2004-01-01), Wakabayashi et al.
patent: 2004/0019035 (2004-01-01), Patane
patent: 2004/0019037 (2004-01-01), Askew et al.
patent: 2004/0019206 (2004-01-01), Ruminiski et al.
patent: 4142366 (1993-06-01), None
patent: WO 98/14192 (1998-04-01), None
patent: WO 98/30542 (1998-07-01), None
patent: WO 99/07405 (1999-02-01), None
patent: WO 02/12501 (2002-02-01), None
patent: WO 2004/020435 (2004-03-01), None
European Search Report dated Aug. 13, 2008, for related European Patent Application No. 05763460.2, filed Mar. 30, 2005.
Bransh, A.D., “A good antisense molecule is hard to find,” Feb. 1998, Trends Biochem Sci., 23(2); 45-50.
Brooks et al. “Insulin-like Growth Factor Receptor Cooperates With Integrin αvβ5 to Promote Tumor Cell Dissemination In Vivo.”J. Clin. Invest. (Mar. 1997), 99(6):1390-1398.
Chorev et al. “Approach to Discovering Novel Therapeutic Agents for Osteoporosis Based on Integrin Receptor Blockade.”Biopolymers(1995), 37:367-375.
Elicieri et al. “Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling.”J. Cell Biol. (Apr. 2002), 157(1):149-159.
Friedlander et al. “Definition of Two Angiogenic Pathways by Distinct αvIntegrins.”Science(Dec. 1995), 270(5241):1500-1502.
Friedlander et al. “Involvement of integrins αvβ3and αvβ5in ocular neovascular diseases.”Proc. Natl. Acad. Sci. USA(Sep. 1996), 93(18):9764-9769.
Goodman et al. “Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins.”J. Med Chem.(2002), 45(5):1045-1051.
Heba et al. “The Time Course of Tumor Necrosis Factor-α, Inducible Nitric Oxide Synthase and Vascular Endothelial Growth Factor Expression in an Experimental Model of Chronic Myocardial Infarction in Rats.”J. Vasc. Res. (2001), 38(3):288-300.
Huang, Xiaozhu et al.; “Normal Development, Wound Healing, and Adenovirus Susceptibility in β5-Deficient Mice”; 2000,Molecular and Cellular Biology, vol. 20, No. 3, pp. 755-759.
Huang, Z., “Structural chemistry and therapeutic intervention of protei-protein interactions in immune response, human immunodeficiency virus entry, and apoptosis,” Jun. 2000, Pharmacol Ther., 86(3), 2001-215.
Hynes, Richard O. “Integrins: Versatility, Modulation, and Signaling in Cell Adhesion.”Cell(Apr. 1992), 69:11-25.
Kakouros et al. “Non-Cardiogenic Pulmonary Edema.”Hellenic J. Cardiol. (2003), 44:385-391.
Li et al. “VEGF,flk-1, andflt-1 expression in a rat myocardial infarction model of angiogenesis.”Am. J. Physiol. (1996), 270(5 Pt 2):H1803-H1811.
Mountain, A., “Gene therapy: the first decade.” Mar. 2000, Trends Biotechnol., 18(3): 119-128.
Pasqualini et al. “A Peptide Isolated from Phage Display Libraries Is a Structural and Functional Mimic of an RGD-binding Site on Integrins.”J. Cell. Biol. (Sep. 1995), 130(5):1189-1196.
Pasqualini et al. “A study of the structure, function and distribution of β5integrins using novel anti-β5monoclonal antibodies.”J. Cell Science(1993), 105:101-111.
Pasqualini et al. “Contrasting Roles for Integrin β1and β5Cytoplasmic Domains in Subcellular Localization, Cell Proliferation, and Cell Migration.”J. Cell Biology(Apr. 1994), 125(2):447-460.
Pasqualini, R., Bodorova, J., Ye, S. and Hemler, M.E., “A study of the structure, function and distribution of beta 5 integrins using novel anti-beta5 monoclonal antibodies,” 1993, J. Cell Sci., 105, 101-111.
Pierschbacher et al. “Manipulation of Cellular Interactions With Biomaterials Toward a Therapeutic Outcome: A Perspective.”J. Cell Biochem. (1994), 56:150-154.
Ruoslahti, E. “RGD And Other Recognition Sequences For Integrins.”Ann. Rev. Cell. Dev. Biol. (1996), 12:697-715.
Smith et al. “Building Synthetic Antibodies as Adhesive Ligands for Integrins.”J. Biol. Chem.(Dec. 1994), 269(52):32788-32795.
Soeki et al. “Serial Changes in Serum VEGF and HGF in Patients with Acute Myocardial Infarction.”Cardiology(2000), 93(3):168-174.
Toole et al., Storming Media: the role of EMMPRIN in Tumor angiogenesis and metastasis, abstract, May 2001.
Wang et al., “A single amino acid determines lysophospholipid specifically of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors,” Dec. 2001, J. Biol. Chem. 276(52): 49213-49220.
Wayner et al. “Integrins αvβ3 and αvβ5 Contribute to Cell Attachment to Vitronectin but Differentially Distribute on the Cell Surface.”J. Cell Biol. (May 1991), 113(4):919-929.
Atakilit Amha
Sheppard Dean
Haddad Maher M
Regents of the University of California
Townsend and Townsend / and Crew LLP
LandOfFree
Methods and compositions for treating and preventing disease... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for treating and preventing disease..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for treating and preventing disease... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4187938