Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-02-02
1994-12-27
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445
Patent
active
053756932
ABSTRACT:
Methods and compositions are disclosed utilizing metabolic derivatives of terfenadine for the treatment of allergic disorders while avoiding the concomitant liability of adverse effects associated with the terfenadine. The metabolic derivatives of terfenadine are also useful for the treatment of retinopathy and other small vessel disorders associated with diabetes mellitus and such other conditions as may be related to the antihistamine activity of terfenadine. For example, the metabolic derivatives of terfenadine are useful for the treatment of asthma, motion sickness, and vertigo, without the concomitant liability of adverse effects associated with terfenadine. Furthermore, the metabolic derivatives of terfenadine, in combination with non-steroidal anti-inflammatory agents or other nonnarcotic analgesics, or in combination with a decongestant, cough suppressant/antitussive or expectorant, are useful for the treatment of cough, cold, cold-like, and/or flu symptoms and the discomfort, headache, pain, fever, and general malaise associated therewith, without the concomitant liability of adverse effects associated with terfenadine.
REFERENCES:
patent: 4254129 (1981-03-01), Carr et al.
Zamani et al., Chemical Abstracts, CA116(17):165681z, 1991.
Chen Yiwang
Woosley Raymond L.
Young James W.
Georgetown University
Henley III Raymond
Jarvis William
Sepracor Inc.
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