Methods and compositions for treating acute or chronic pain and

Details Methods and compositions for treating acute or chronic pain and Methods and compositions for treating acute or chronic pain and

1992-08-07

1993-10-26

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514561, A61K 3144, A61K 31195

Patent

active

052566692

ABSTRACT:
Methods and compositions for treating acute or chronic pain in a mammal comprising administering a therapeutically effective amount of an analgesic solution comprising at least one branched chain amino acid selected from the group consisting of leucine, isoleucine, and valine, or administering a therapeutically effective amount of an analgesic solution comprising an analgesic agent selected from the group consisting of an opioid, an agonistic-antagonistic agent, and an anti-inflammatory agent, and at least one branched chain amino acid selected from the group consisting of leucine, isoleucine, and valine. A method and composition for treating addiction to narcotic drugs comprises administering a therapeutically effective amount of a solution comprising methadone and at least one branched chain amino acid selected from the group consisting of leucine, isoleucine, and valine.

REFERENCES:
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patent: 5017616 (1991-05-01), Askanazi
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Kirvela, O. et al., Acta Anasesth. Scand. 34:645-648, "Respiratory and sleep patterns during nocturnal infusion of branched chain amino acids" (1990).
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Keefe, F. J., Advances in Pain Measurement, vol. 12, "Behavioral measurement of pain", pp. 405-424 (C. R. Chapman and J. D. Loeser, eds.) (Raven Press 1989).
G. Woolfe and A. D. MacDonald,"The evaluation of the analgesic action of pethidine hydrochloride Demerol", J. Pharmacol. Exp. Ther. 80:300-307 (1944).
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