Methods and compositions for therapeutic uses of a fibrin-specif

Details Methods and compositions for therapeutic uses of a fibrin-specif Methods and compositions for therapeutic uses of a fibrin-specif

1995-06-02

1998-03-03

Loring, Susan A.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241581, 4241811, 4241831, 4241791, 53038825, 5303881, 5303911, 5303917, 5303915, A61K 39395, C07K 1618

Patent

active

057231265

ABSTRACT:
The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides methods for the use of such monoclonal antibodies, and polyclonal antibodies derived from an immunized germfree animal, for in vitro and in vivo clinical diagnostics and therapeutics. Also, the subject invention provides a fibrin-specific monoclonal antibody.

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Bode, C. et al., Science, 229(H715):765-767, 1985.
Vitetta, E. S. et al, Transplantation, 37(6) 535-538, 1984.
Lee, F.H. et al, Fed. Proc, 36(3):5154, 1977.
Lee, F.H. et al, Cancer Immunol Immunother, 5:201-206, 1978.
DeNardo, S.J. et al, J. Nucl Med., 29(5):899, May 1988.

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