Methods and compositions for the use of 2-carboxy-5-oxo-5H-diben

Details Methods and compositions for the use of 2-carboxy-5-oxo-5H-diben Methods and compositions for the use of 2-carboxy-5-oxo-5H-diben

1975-03-31

1977-07-12

Myers, Jane S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260211R, 2602472B, 260253, 260268R, 26029362, 2603096, 424316, 26032633, 260429R, 2604299, 2604381, 260439R, 260448R, 260469, 260472, 2605011, 26050111, 26050113, 26050117, 260515R, 424180, 42424855, 424250, 424253, 424267, 424273, 424274, 424287, 424289, 424294, 424295, 536 18, 424308, 424310, A61K 3119, A61K 31205, A61K 31235

Patent

active

040355098

ABSTRACT:
2-Substituted-5-oxo-5H-dibenzo[a,d]cycloheptenes represented by the following formula: ##STR1## where R' is hydrogen, alkyl having 1 to 12 carbon atoms, or ##STR2## where n is an integer from 2 to 4, inclusive, and R.sup.4 and R.sup.5 are independently lower alkyl having 1 to 6 carbon atoms or together R.sup.4 and R.sup.5 and the nitrogen atom to which they are attached form a heterocyclic ring having 5 or 6 total ring atoms; and the pharmaceutically acceptable salts thereof. The compounds are useful in the treatment of auto-immune diseases and allergic reactions.

REFERENCES:
patent: 3256335 (1966-06-01), Slates et al.
patent: 3468939 (1969-09-01), Kaltenbionn
patent: 3600437 (1971-08-01), Marshall
patent: 3624142 (1971-11-01), Shen et al.
patent: 3641134 (1972-02-01), Shen et al.
patent: 3803234 (1974-04-01), Dostert et al.
patent: 3864493 (1975-02-01), Cairns et al.
patent: 3879544 (1975-04-01), Reisner et al.
patent: 3883593 (1975-05-01), Berezin et al.
patent: 3883653 (1975-05-01), Barth
patent: 3885038 (1975-05-01), Pfister et al.
Gomes, C. R. Acad. Sc. Paris, t.274, Serie C, pp. 73-76 (1976).
The Merck Manual, pp. 612-617, 1209-1219 and 1252-1255.
Ebnoether et al., as cited in C.A. 63, 17997 (1965).

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