Methods and compositions for the treatment of psoriasis

Details Methods and compositions for the treatment of psoriasis Methods and compositions for the treatment of psoriasis

1987-06-09

1989-02-14

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514863, 514934, A61K 3170

Patent

active

048046515

ABSTRACT:
Disclosed are methods and compositions employing azidothymidine for the treatment of psoriasis. Oral, parenteral or topical dosage forms are administered to affected individuals in therapeutically effective amounts. Typically, between about 100 and about 4000 mg of azidothymidine is administered orally per day until symptoms of the disease such as inflammation, irritation, or incidence or size of lesions, are abated. Also disclosed are topical dosage forms, including pharmaceutically acceptable creams, lotions, ointments, salves and the like, which include therapeutically effective concentrations of azidothymidine. Such topical compositions may further include effective amounts of a corticosteroid or a cutaneous surface acting antipsoriatic agent, such as a keratolytic agent.

REFERENCES:
Christophers et al. (1986), "Psoriasis", Chapter 42 of Dermatology in Medicine, 3rd Edition, Fitzpatrick et al., eds., pp. 461-491.
Summary Report, Retrovir (Zidovudine), (1987), Investigators/Clinicians Forum Held Dec. 20, 1987.
The Retrovir (Zidovudine) distribution program (1987).
Retrovir (Zidovudine), From Discovery to Patient, date unknown.
Ruzicka et al. (1987), The Lancet, Dec. 19, 1987, pp. 1469-1470.
Burrough's Wellcome protocol--"Uncontrolled Clinical Trial of the Long Term Safety of AZT".
NIAID Backgrounder, "ATEU Investigators Plan AZT Studies" Sep., 1986.
NCI Cancer Facts, "Azidothymidine Research at NCI" Sep., 1986.
Anderson et al., "Psoriasis in Pathogenesis of Skin Disease", pp. 67-84.

Affiliated with

Also associated with

Rating

Methods and compositions for the treatment of psoriasis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for the treatment of psoriasis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the treatment of psoriasis will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1365632