Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-05-31
2005-05-31
Weber, Jon (Department: 1653)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C435S007100, C435S183000, C435S320100, C435S325000, C424S085100, C514S012200, C530S350000, C536S023100
Reexamination Certificate
active
06900041
ABSTRACT:
The present invention is directed to compositions and methods for treating inflammatory diseases comprising administration of compositions that effect glycogen synthase kinase 3β (GSK-3β) protein or gene. The present invention also comprises methods and compositions for the identification of compounds or therapeutic agents which modulate the activity of the protein. The present invention provides compositions for and methods off treatment of biological conditions including, but not limited to, type I and type II diabetic induced vasculopathy, other vasculopathies, asthma and inflammation-induced diseases such as atherosclerosis and cell proliferation.
REFERENCES:
patent: 6479490 (2002-11-01), Gong et al.
patent: 2002/0086282 (2002-07-01), Phullarisetti et al.
Badrichani, A.Z., et al., “Bcl-2 and Bcl-XLServe an Anti-Inflammatory Function in Endothelial Cells Through Inhibition of NF-κB”, The Journal of Clinical Investigation, vol. 103, No. 4: pp. 543-553 (1999).
Banba, Nobuyuki, et al., “Possible Relationship of Monocyte Chemoattrractant Protein-1 With Diabetic Nephropathy”, Kidney International, vol. 58, No. 2: pp. 684-690 (2000).
Beg, Amer A, et al., “An Essential Rose for NF-κB in Preventing TNF-α-Induced Cell Death”, Science, vol. 274: pp. 782-784 (1996).
Cross, Darren A.E., et al., “Inhibition of Glycogen Synthase Kinase-3 by Insulin Mediated by Protein Kinase B”, Nature, vol. 378, No. 6559: pp. 785-789 (1995).
Fiol, Carol J., et al., “A Secondary Phosphorylation of CREB341at Ser129is Required for the cAMP-mediated Control of Gene Expression”, The Journal of Biochemistry, vol. 269, No. 51: pp. 32187-32193 (1994).
Green, E. Allison, et al., “Tumor Necrosis Factor-α and the Progression Of Diabetes in Non-Obese Diabetic Mice”, Immunological Reviews, vol. 169: pp. 11-22 (1999).
Hanger, Diane P., et al., “Glycogen Synthase Kinase-3 Induces Alzheimer's Disease-Like Phosphrylation of Tau: Generation of Paired Helical Filament Epitopes and Neuronal Localisation of the Kinase”, Neuroscience Letters, vol. 147: pp. 58-62 (1992).
Kim, Leung, et al., “GSK3, a Master Switch Regulating Cell-Fate Specification and Tumorigenesis”, Current Opinion in Genetics & Development, vol. 10, No. 5: pp. 508-514 (2000).
Klein, Peter S. et al., “A Molecular Mechanism for the Effect of Lithium on Development”, Pro. Natl. Acad. Sci. USA, vol. 93, No. 15: pp. 8455-8459 (1996).
Laight, David W. et al., “Endothelial Cell Dysfunction and the Pathogenesis of Diabetic Macroangiopathy”, Diabetes Metab. Res. Rev., vol. 15, No. 4: pp. 274-282 (1999).
Lau, K.F. et al., “Expression Analysis of Glycogen Synthase Kinase-3 in Human Tissues”, J. Peptide Res., vol. 54, No. 1: pp. 85-91 (1999).
Lesort, Matheiu, et al., “Insulin Transietnly Increases Tau Phosphorylation: Involvement of Glycogen Synthase Kinase-3β and Fyn Tyrosine Kinase”, Journal of Neurochemistry, vol. 72, No. 2: pp. 576-584 (1999).
Raj, M.D., Dominic S.C. et al., “Advanced Glycation End Products: A Nephrologist's Perspective”, American Journal of Kidney Diseases, vol. 35, No. 3: pp. 365-380 (2000).
Read, Margaret A.. et al., “NF-κB and IκBα: An Inducible Regulatory System in Endothelial Activation”, Journal of Experimental Medicine, vol. 179, Nos. 1-3: pp. 503-512 (1994).
Ross, Sarah H., et al., “Glycogen Synthase Kinase 3 Is an Insulin-Regulated C/EBPα Kinase”, Molecular and Cellular Biology, vol. 19, No. 12: pp. 8433-8441 (1999).
Stambolic, Vuk, et al., “Lithium Inhibits Glycogen Synthase Kinase-3 Activity and Mimics Wingless Signalling in Intact Cells”, Current Biology, vol. 6, No. 12: pp. 1664-1668 (1996).
Stehouwer, Coen D.A.., et al., “Endothelial Dysfunction and Pathogenesis of Diabetic Angiopathy”, Cardiovascular Research, vol. 34: pp. 55-68 (1997).
Summers, Scott A., et al., “The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism”, The Journal of Biological Chemistry, vol. 274, No. 25: pp. 17934-17940 (1999).
Sutherland, Calumn, et al., “Inactivation of Glycogen Synthase Kinase-3β by Phosphorylation: New Kinase Connections in Insulin and Growth-Factor Signalling”, Biochemical Journal, vol. 296: pp. 15-19 (1993).
Tracey, Kevin J., et al. “Tumor Necrosis Factor, Other Cytokines and Disease”, Annu. Rev. Cell Biol., vol. 9: pp. 317-343 (1993).
Van Antwerp, Daniel J., et al., “Suppression of TNFα -Induced Apoptosis by NF-κB”, Science, vol. 274: pp. 787-789 (1996).
Welsh, Gavin, et al., “GSK3: a Shaggy Frog Story”, Trends in Cell Biology, vol. 6: pp. 274-279 (1996).
Wilson, Byron E., et al., “Induction of blc-2 Expression by Phosphorylated CREB Proteins during B-Cell Activation and Rescue from Apoptosis”, Molecular and Cellular Biology, vol. 16, No. 10: pp. 5546-5556 (1996).
Cahoon Shianlen
Pillarisetti Sivaram
Saxena Uday
Vines Angela
Kam Chih-Min
Reddy US Therapeutics Inc.
Weber Jon
Womble Carlyle Sandridge & Rice PLLC
LandOfFree
Methods and compositions for the treatment of inflammatory... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for the treatment of inflammatory..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the treatment of inflammatory... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3410146