Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1991-09-06
1993-12-14
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424422, 424423, 424424, 424425, 424426, 424450, 424484, 424489, 424499, 514 2, 514 8, 514 56, 514944, 514965, 530350, 530351, 530353, 530354, 530356, 530840, C07K 1506, C09H 302, A61K 3722, A61K 3724, A61K 3736
Patent
active
052703002
ABSTRACT:
Methods and compositions are provided for the treatment and repair of defects in the cartilage or bone of humans and other animals as in full-thickness defects in joints. The defect in bone is filled with a matrix having pores large enough to allow cells to populate the matrix and to form blood vessels. The matrix filling the bone defect contains an angiogenic factor and also contains an osteogenic factor in an appropriate delivery system. To induce cartilage formation, a defect in cartilage is filled with a matrix having pores sufficiently large to allow cartilage repair cells to populate the matrix. The matrix filling the defect in cartilage contains a proliferation agent and also contains a transforming factor in an appropriate delivery system. The matrix may also contain a chemotactic agent to attract cartilage repair cells. In a full-thickness defect, the defect sites in bone and cartilage are separated from each other by a membrane, which is sealed to the cartilage-bone-junction and which prevents blood vessels and associated cells from penetrating from one site to the other.
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Kulyk, W.
Griffin Ronald W.
Massaro Jane A.
Mullowney Edward F.
Shaw Robert Francis
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