Methods and compositions for the selective regulation of chorion

Details Methods and compositions for the selective regulation of chorion Methods and compositions for the selective regulation of chorion

1995-06-07

2000-04-11

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Hormone or other secreted growth regulatory factor,...

514 2, 514 12, A61K 3900, A61K 3800, A01N 3718

Patent

active

060485345

ABSTRACT:
Methods for inhibiting the production of specific vasoconstrictive prostanoids, such as thromboxane and prostaglandin F.sub.2.alpha., through the addition of insulin-like growth factor, particularly IGF-I or IGF-II, to human placental cells are disclosed. IGF-I is demonstrated to avoid affecting material and placental production of prostaglandin E.sub.2, human chorionic gonadotropin, PGFM, and 6-keto-PGF1-alpha by placental cells. Improved methods for vasoregulation of vasoconstrictive diseases of pregnancy are also disclosed. Methods for treating intrauterine growth retardation and hypertension with IGF-I are described. Improved methods for inhibiting pre-term labor are provided. Methods for inducing labor with agents that specifically inhibit insulin-like growth factor are also disclosed. Such inhibitors of IGF-I include antibodies, antagonists of IGF-I, and metabolizing enzymes of IGF-I.

REFERENCES:
patent: 5420111 (1995-05-01), Gluckman et al.
Vane et al., British Journal of Pharmacology, 48:629-39, 1973.
Johnson et al., American Journal of Obstetrics and Gynecology, 123(4):364-75, 1975.
Geisthovel. et al., Human Reproduction, 5(7):785-799, 1990.
Siler-Khodr, 38.sup.th Annual Meeting of the Society for the Study of Reproduction, (Raleigh, NC), Abstract#513:178, 1992.

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