Methods and compositions for the repair of articular cartilage d

Details Methods and compositions for the repair of articular cartilage d Methods and compositions for the repair of articular cartilage d

1995-06-06

1998-03-03

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Primate cell, per se

435325, 435395, 435397, 424423, 623 11, C12N 500, C12N 502

Patent

active

057233314

ABSTRACT:
Provided are methods and compositions for the repair of articular cartilage defects in a mammal. Denuded chondrogenic cells are proliferated ex vivo as monolayer cultures in order to expand the pool of available chondrogenic cells. During proliferation the chondrogenic cells stop secreting the extracellular matrix components, type II collagen and sulfated proteoglycans. The proliferated cells then are seeded into a pre-shaped well having a cell contacting, cell abhesive surface. The cells cultured in the well redifferentiate and begin to secrete cartilage-specific extracellular matrix again. Accordingly, essentially unlimited amounts of synthetic cartilage may be prepared from small samples of biopsy tissue. Also provided are methods for surgically repairing articular cartilage defects in mammals using the synthetic cartilage prepared in accordance with the invention.

REFERENCES:
patent: 5206023 (1993-04-01), Hunziker

Affiliated with

Also associated with

Rating

Methods and compositions for the repair of articular cartilage d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for the repair of articular cartilage d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the repair of articular cartilage d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2246774