Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1994-06-14
1999-03-02
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
435 6, 435 693, 4352523, 43525233, 4353201, 530350, 536 235, 935 12, 935 27, 935 31, 935 73, C12N 1530, C12N 1500, C12N 1570, C07K 1444
Patent
active
058769854
ABSTRACT:
Disclosed are methods and compositions for the recombinant preparation of Trichomonas vaginalis proteins and peptides, including recombinant DNA segments encoding such proteins or peptides. In particular, techniques are disclosed for the preparation of recombinant clones which comprise T. vaginalis DNA segments encoding proteins or peptides which are expressed essentially only in Type I or Type II isolates, such as protein P55, a protein which is uniquely expressed in Type II isolates. Additionally, techniques for the preparation of proteins or peptides encoding epitopes of protein P270 are disclosed, as well as a detailed characterization of the P270 protein based on the characterization of a recombinant clone encoding the epitope of the parent protein. The invention further discloses the fact that a protein, termed P230, is the immunodominant surface protein in which vaginal antibody is elicited in vaginitis associated with T. vaginalis infections, as well as techniques for preparing recombinant clones encoding such a protein. Associated aspects involve the application of immunological or hybridization based techniques involving one or more of the foregoing compositions.
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Board of Regents , The University of Texas System
Moore William W.
Patterson Jr. Charles L.
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