Methods and compositions for the preparation and use of site-dir

Details Methods and compositions for the preparation and use of site-dir Methods and compositions for the preparation and use of site-dir

1989-06-20

1992-06-30

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

514 2, 514 13, 514 14, 514 15, 514 16, C08G 6348, C08G 6391, A01N 3718

Patent

active

051263998

ABSTRACT:
Disclosed are peptidyl-resin conjugates made up of an immunogenic/antigenic peptide conjugated to a polyamide resin, wherein the peptide incorporates a helper T-cell epitope. The inclusion of a T-cell epitope in this peptide sequence provides particular benefits in the preparation of site-directed reagents intended as immunogens. In exemplary studies, a synthetic peptide predicted from Abelson murine leukemia virus abl oncogene (residues 389-403) was synthesized with a T-cell active epitope of 7 amino acids placed at its N-terminus (T-abl-resin). The T-abl-resin construct was found to greatly stimulate the immune response giving significantly higher specific antibody titers than abl-resin controls.

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