Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-10-15
1995-09-19
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424400, A61K 3818, A61K 962
Patent
active
054514118
ABSTRACT:
Alginate beads are employed as a site specific oral delivery system for cationic therapeutic agents, such as TGF-.beta..sub.1, designed to target the agents to the luminal side of the small intestine. Improved delivery of bioactive material is obtained by: 1) incorporating selected polyanions in the alginate beads to shield the cationic therapeutic agent from interaction with alginate and/or 2) acid treating alginate beads containing the therapeutic agents to reduce the molecular weight of alginate and its interaction with the agents. Enhanced bioactivity of therapeutic agents released from the alginate is attributed to the ability of polyacrylic acid to shield the agents from interaction with lower molecular fragments of acid treated alginate.
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Bouchard Lisa S.
Gombotz Wayne R.
Hoffman Allan S.
Mumper Russell J.
Bristol Myers Squibb Company
Kulkosky Peter F.
Page Thurman K.
University of Washington
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