Methods and compositions for the monitoring and quantitation of

Details Methods and compositions for the monitoring and quantitation of Methods and compositions for the monitoring and quantitation of

1995-03-15

1999-08-03

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 243, 536 2431, 536 2433, C12Q 168, C07H 2104

Patent

active

059324147

ABSTRACT:
Methods and compositions for monitoring the presence of minimal residual hematopoietic tumor cells, such as T-cell acute lymphoblastic leukemia cells, in remission cells of a patient. The invention relates to using nucleic acid hybridization probes to detect alteration of tal-1 locus on chromosome 1 from a DNA extract to confirm the presence of residual T-cell acute lymphoblastic leukemia cells in the patient. Methods to quantitate the amount of hematopoietic cells are described. Kits for detecting and monitoring hematopoietic tumor cells in a patient are provided. Kits for quantitating hematopoietic tumor cells in a patient in remission are also provided.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
Chen et al., EMBO, vol. 9, No. 2, pp. 415-424, 1990.
Finger et al., PNAS, vol. 86, pp. 5039-5043, Jul. 1989.
Gabert et al., Tl Lancet, 11 Nov., 1989, pp. 1125-1127.

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