Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds allergen or component thereof
Patent
1993-11-24
1997-07-01
Eisenschenk, Frank C.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds allergen or component thereof
4241301, 5303871, 5303881, 53038815, 530863, 530862, 530868, C07K 1600, A61K 39395
Patent
active
056435720
ABSTRACT:
The present invention provides novel compositions and methods useful in the, modulation or selective suppression of host immune responses to an immunogen of interest, particularly exogenous antigens and allergens such as urushiol, the active plant component causing poison ivy/oak contact sensitivity. The subject compositions are antibody molecules of either Ab.sub.1 or Ab.sub.2 (anti-idiotypic) reactivity with respect to the sensitizing antigen. Other compositions include specific T cell receptor (TCR) molecules either as T cell clones or hybridomas or as TCR preparations. Immunogenic peptides corresponding to some or all of the complementary determining regions or hyper-variable regions of the TCR are also employed. Such compositions suppress host immune responses to antigen by a variety of pathways including anti-idiotypic interactions with cells involved in antigen processing and stimulation of the immune network. T cell receptor molecules and immunogenic peptides corresponding to regions of the TCR also suppress immune responses by interactions with the immunoregulatory network.
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Baldwin Robert W.
Byers Vera K.
Allergene, Inc.
Eisenschenk Frank C.
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