Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2006-11-07
2006-11-07
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S015000, C435S032000, C435S193000, C424S009200
Reexamination Certificate
active
07132234
ABSTRACT:
The invention provides methods for identifying an anti-poxviral agents. In many embodiments, the methods involve contacting a poxviral p28 polypeptide with a candidate agent, and determining an effect of the agent on a ubiquitin ligase activity of the p28 polypeptide. The effect of the agent may be determined using a variety of different cell based or biochemical assays, such as polyubiquitylation assays and cell viability assays. The invention also provides methods for modulating poxvirus pathogenicity in a cell, and methods of treating an individual infected with a poxvirus. The subject methods find use in a variety of drug discovery, research and military applications.
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patent: 2002/0042083 (2002-04-01), Issakani
patent: WO 01/75145 (2001-10-01), None
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Huang Jianing
Lu Henry H.
Payan Donald G.
Diehl James J.
Francis Carol L.
Keddie James S.
Mosher Mary E.
Rigel Pharmaceuticals Inc.
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