Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-05-15
1996-06-25
Feisee, Lila
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303884, 604 46, 604 93, 606 76, C07K 1612, C07K 1608, A61B 1720, A61M 2500
Patent
active
055301029
ABSTRACT:
Compositions containing a high concentration of the full repertoire of immunoglobulins, including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound, surgical, or burn site, or normal tissue at times of risk of infection. The compositions can contain elevated antibody titers for several specific pathogens including S. aureus, CNS, Enterococci, S. epidermidis, P. aeruginosa, E. coli, and Enterobacter spp., etc. The compositions are applied directly to a wound or burn site as an ointment, creme, fluid, spray, or the like, prior to viral or bacterial attachment or biofilm formation such that adhesion of the pathogens is inhibited and the pathogens closest to the wound or burn site will be pre-opsonized for phagocytic killing prior to toxin release. The immunoglobulins in the composition can be immobilized on a biocompatible material such as collagen, fibrin, hyaluronan, biodegradable polymers, and fragments thereof, which will be placed in-situ at the wound, surgical or burn site. In addition, the immunoglobulins in the composition may be coated on the body contacting surface of an implantable device such as a catheter, contact lens or total joint. The inventive compositions have particular application in preventing infections.
REFERENCES:
patent: 4994269 (1991-02-01), Collins
patent: 5273527 (1993-12-01), Schatz
Collins, M. S. et al., Infection 15 Suppl 2:S51-59, 1987.
Siber et al, New England Journal of Medicine, 327(4): 269-271.
Horan et al., Antimicrobial Newsletter, 5(9): 66-68, Sep. 1988.
Mandell (ed.) Principles and Practice of Infectious Diseases, 2nd edt, John Wiley & Sons, chapter 5, pp. 37-43.
Siber et al, Current Clinical Topics in Infectious Disease, vol. 12, pp. 208-256.
Gristina Anthony G.
Myrvik Quentin N.
Feisee Lila
Loring Susan A.
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