Methods and compositions for the direct concentrated delivery of

Details Methods and compositions for the direct concentrated delivery of Methods and compositions for the direct concentrated delivery of

1996-02-29

1998-01-13

Loring, Susan A.

Drug, bio-affecting and body treating compositions

Live skin colorant containing

Lip

4241501, 4241301, 4241631, 4241651, 4241691, 4241701, 5303871, 5303881, 5303882, 5303884, 5303891, 5303895, A61K 3940, A61K 39085, A61K 3909, A61K 39104

Patent

active

057076278

ABSTRACT:
Compositions containing a high concentration of the full repertoire of immunoglobulins, including IgA, IgM and IgG, are used to combat infections from microorganisms and viruses at a wound, surgical, or burn site, or normal tissue at times of risk of infection. The compositions can contain elevated antibody titers for several specific pathogens including S. aureus, CNS, Enterococci, S. epidermidis, P. aeruginosa, E. coli, and Enterobacter spp., etc. The compositions are applied directly to a wound or burn site as an ointment, creme, fluid, spray, or the like, prior to viral or bacterial attachment or biofilm formation such that adhesion of the pathogens is inhibited and the pathogens closest to the wound or burn site will be pre-opsonized for phagocytic killing prior to toxin release. The immunoglobulins in the composition can be immobilized on a biocompatible material such as collagen, fibrin, hyaluronan, biodegradable polymers, and fragments thereof, which will be placed in-situ at the wound, surgical or burn site. In addition, the immunoglobulins in the composition may be coated on the body contacting surface of an implantable device such as a catheter, contact lens or total joint. The inventive compositions have particular application in preventing infections.

REFERENCES:
patent: 4412990 (1983-11-01), Lundblad et al.
patent: 4714612 (1987-12-01), Nakamura et al.
patent: 4770875 (1988-09-01), Kume et al.
patent: 4783989 (1988-11-01), Hook et al.
patent: 4859769 (1989-08-01), Karlsson et al.
patent: 4957735 (1990-09-01), Huang
patent: 4957739 (1990-09-01), Berget et al.
patent: 4980462 (1990-12-01), Karlsson et al.
patent: 4994269 (1991-02-01), Collins et al.
Gristina, "Biomaterial-Centered Infection, Microbial Adhesion Versus Tissue Integration", Science, vol. 237, 25 Sep. 1987, pp. 1588-1595.
Gristina et al., "Biomaterial-Centered Sepsis and the Total Artificial Heart", Journal of the AmericalnMedical Association (JAMA), vol. 259, Feb. 12, 1988, pp. 870-874.
Gristina et al., "Molecular Mechanisms in Musculoskeletal Sepsis: The Race for the Surface", Instructional Course Lectures, vol. XXXIX 1990, American Academy of Orthopaedic Surgeons, pp. 471-482.
Buckley et al., "The Use of Intravenous Immune Globulin in Immunodeficiency Diseases", New England Journal of Medicine, Jul. 11, 1991, pp. 110-117.
Cometta et al., "Prophylactic Intraveous Administration of Standard Immune Globulin . . . ", New England Journal of Medicine, vol. 327, No. 4, Jul. 23, 1992, pp. 234-239.
Siber et al., "Use of Immune Globulins in the Prevention and Treatment of Infections", Current Clinical Topics in Infectious Diseases, vol. 12 pp. 208-256.
Panlilio et al., "Methicillin-Resistant Staphylococcus Aureus in U.S. Hospitals, 1975-1991", Infection Control and Hospital Epidemiology, vol. 13, No. 10, Oct. 1992, pp. 582-586.
Emori et al., "Nosocomial Infections in Elderly Patients in the United States, 1986-1990", American Journal of Medicine, vol. 91(suppl 3B), pp. 3B-289S-293S.
Siber, "Immune Globulin to Prevent Nonsocomial Infections", New England Journal of Medicine, vol. 327,No. 4, pp. 269-271.
Ma, "Prevention of Colonization of Streptococcus Mutans by Topical Application of Monoclonal Antibodies . . . ", Arch Oral Biol 1990; 35 Suppl;115S-122S (abstract).
Gristina, "Materials, Microbes and Man: the Problem of Infecton Associated with Implantable Devices", Current Perspectives on Implantable Devices, vol. 1, JAI Press Inc., pp. 71-137.
Gristina, "Biomaterial Specificity, Molecular Mechanisms and Clinical Relevance of S. epidermidis and S. aureus Infections in Surgery", Zbl. Bakt. Suppl. 16, Gustav Fischer Verlag, 1987.
Kojima, "Antibody to the Capsular Polysaccharide/Adhesion Protects Rabbits . . . ", Journal of Infectious Diseases 1990;162, Aug., pp. 435-441.
Mandell (ed.), Principles and Practice of Infectious Diseases, 2nd Ed., John Wiley and Sons, 19?, Chapter 5, pp. 37-43.
Behre et al., "Endotoxin Concentration in Neutropenic Patients with Suspected Gram-Negative Sepsis", Antimicrobial Agents and Chemotherapy, vol. 36, No. 10, Oct. 1992, pp. 2139-2146.
van Furth et al., "Correlation Between Opsonic Activity fo Various Micoorganisms and Composition of Gammaglobulin Preparations for Intravenous Use", Journal of Infectious Diseases, Vo. 149, No. 4, Apr. 1984, pp. 511-517.
Givner et al., "A Polyclonal Human IgG Preparation Hyperimmune for Type III, Group B Streptococcus", Journal of Infectous Diseases, vol. 158, No. 4, Oct. 1988, pp. 724-728.
Emori et al., "National Nosocomial Infections Surveillance System (NNIS) . . . ", American Jouranl of Infection Control, vol. 19, No. 1, Feb. 1991, pp. 19-35.
Culver et al., "Surgical Wound Infection Rates by Wound Class, Operative Procedure, and Patient Risk Index", American Journal of Medicine, vol. 91(Suppl 3B), Sep. 16, 1991, pp. 3B-152-S -3B-157S.
.sub.--, "Nosomial Infection Rates for Interhospital Comparison . . . ", Infection Control and Hospital Epidemiology, vol. 12, No. 10, pp. 609-621.
Jarvis et al., "Nosocomial Infection Rates in Adult and Pediatric Intensive Care Units in the United States", American Journal of Medicine, vol. 91(Supp3B) Sep. 16, 1991, pp. 185S-191S.
Horan et al., "Pathogens Causing Nosocomial Infections", Antimicrobic Newsletter, vol. 5, No. 9, Sep. 1988, pp. 66-68.
MedImmune, Inc. 1991 Annual Report.
Pirofski et al., "Current State of the Hybridoma Technology", Journal of Clinical Immunology, vol. 10, No. 6 (Nov. Suppl. 1990), pp. 5S-14S.
Dwyer, "Manipulating the Immune System With Immune Globulin", New England Journal of Medicine, vol. 326, No. 2, Jan. 9, 1992, pp. 107-116.
Givner, "Human Immunoglobulins for Intravenous Use . . . ", Pediatrics, vol. 86, No. 6, Dec. 1990, pp. 955-962.
Steinman, "The Use of Monoclonal Antibodies for Treatment of Autoimmune Disease", Journal of Clinical Immunology, vol. 10, No. 6, (11/90 Supp) pp. 30S-39S.
Waldmann et al. "Lymphokine Receptor-Directed Therapy: A Model of Immune Intervention", Journal of Clinical Immunology, vol. 10, No. 6 (11/90 Supp) pp. 19S-29S.
Vitetta, "Immunotoxins: New Therapeutic Reagents for Autoimmunity, Cancer and AIDS, Journal of Clinical Immunology", vol. 10, No. 6 (11/90 Supp), pp. 15S-18S.
"Investment Opinion and Summary", Smith Barney, Aug. 31, 1992.
Gristina et al., "Microbes, Metals, and Other Nonbiological Substrate in Man", Orthopaedic Infection, W.B. Saunders Co., 1989, Chapter 3, pp. 26-36.
Gristina et al., "Microbial Adhesion and the Pathogenesis of Biomaterial-Centered Infections", Orthopaedic Infection, W.B. Saunders Co., 1989, Ch 2, pp. 3-25.
Gristina et al., "Biomaterial-Centered Infections: Microbial Adhesion versus Tissue Integration", Pathogenesis of Wound and Biomaterial-Associated Infections, Springer-Verlag, pp. 193-216.
Anwar et al., "Effective Use of Antibiotics in the Treatment of Biofilm-Associated Infections", ASM News, vol. 58, No. 12, 1992, pp. 665-668.
Casadevall et al., "Serum Therapy Kevisited: Animal Models of Infection and Development of Passive Antibody Therapy" Antimicrobial Agents and Chemotherapy, Aug. 1994, pp. 1695-1702.
Collins, M.S. et al, Infection, 15 Suppl. 2:551-559, 1987.
Sherertz et al., "Efficacy of Antibiotic-Coated Catheters in Preventing Subcutaneous Staphylococcus aureus Infection in Rabbits", Journal of Infectious Diseases, 167:98-106, 1993.
Seligson et al., "The Use of Antibiotic-Impregnated Polymethylmethacrylate Beads to Prevent the Evolution of Localized Infection," Journal of Orthopedic Trauma, vol. 6 No. 4, pp. 401-401 (1992).
Collins et al., "Therapy of Experimental Pseudomonas Aeruginosa burn wound sepsis with human immunoglobulin G. Pseudomonas hyperimmune immunoglobulin G, and antibiotics, The Pathophysiology of Combined Injury and Trauma", Eds. Gruber, Walker, MacVittie and Conklin, Academic Press, 1987.
Norden, "Osteomyelitis: Lessons from Animal Models and Clinical Application," Musculoskeletal Infection Eds. Esterhai, Gristina, Poss, American Academy of Orthopaedic Surgeons, Dallas, Texas, 1990.
Norden, "Lessons Learned from Animal Models in Osteomyelitis," Review of Infectious Diseases, Jan.-Feb. 1988, 1

Affiliated with

Also associated with

Rating

Methods and compositions for the direct concentrated delivery of does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for the direct concentrated delivery of, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for the direct concentrated delivery of will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-324093