Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-04-13
2011-10-04
Bristol, Lynn (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
08030013
ABSTRACT:
Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A, LYVE1, Ecadherin, IGFBP3, PDGFRA, TGFA, cyclin D1 and HGF are differentially expressed in HCC as compared to normal liver cells and liver cells that have dysplastic, non-cancerous nodules.
REFERENCES:
patent: 2009/0035290 (2009-02-01), Chen et al.
patent: WO2004/108964 (2004-12-01), None
Ikeguchi et al. (Clin. Can. Res. 8:3131-3136 (2002).
Ikeguchi et al. (Cancer 95(9):1938-1345 (2002)).
Colombat et al. (J. Pathol 201:260-267 (2003)).
Lencioni et al., J. Hepatol., 40:162-171 (2004).
Friedman Scott L.
Llovet Josep M.
Schwartz Myron
Bristol Lynn
Marshall & Gerstein & Borun LLP
Mount Sinai School of Medicine
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