Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-08-30
1999-01-12
Huff, Sheela
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 5303877, 5303888, 4241381, G01N 3353
Patent
active
058586830
ABSTRACT:
The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with a labeled binding moiety, for example, a labeled antibody capable of binding specifically to the protein. The invention also provides kits useful in the detection of cervical cancer in an individual. In addition, the invention provides methods utilizing the cervical cancer-associated proteins either as targets for treating cervical cancer or as indicators for monitoring of the efficacy of such a treatment.
REFERENCES:
patent: 4474893 (1984-10-01), Reading
patent: 4722899 (1988-02-01), Hamaoka et al.
patent: 4775620 (1988-10-01), Cardiff et al.
patent: 4882268 (1989-11-01), Penman et al.
patent: 4885236 (1989-12-01), Penman et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5098890 (1992-03-01), Gerwirtz et al.
patent: 5273877 (1993-12-01), Fey et al.
patent: 5350835 (1994-09-01), Gaynor et al.
patent: 5547928 (1996-08-01), Wu et al.
patent: 5688511 (1997-11-01), Gaynor et al.
Seaver et al Genetic Engineering News vol. 14 No. 14 pp. 10 and 21, Aug. 1994.
Sevier et al Clinical Chemistry vol. 27 No. 11 1797-1806, 1981.
Smedts et al., "Basal-cell keratins in cervical reserve cells and a comparison to their expression in cervical intraepithelial neoplasia," Am. J. Pathology, 140(3):601-612, 1992.
Petrov et al., "The expression of cytokeratin No. 17 in squamous cell cancer of the cervix uteri: an immunohistochemical study of 19 cases," Voprosy Onkologii, 38(7):797-805 (1992), Abstract only.
Berezney et al., "Identification of a nuclear matrix protein", Biochem. Biophys. Res. Commun. 60:1410-1417 (1974).
Bidwell et al., "Nuclear Matrix Proteins Distinguish Normal Diploid Osteoblasts from Osteosarcoma Cells", Cancer Research, 54:28-32 (1994).
Bidwell et al., "Osteocalcin Gene Promoter Binding Factors are Tissue-Specific Nuclear Matrix Components," Proc. Natl. Acad. Sci. USA 90:3162-3166, 1993.
Brancolini et al., "Change in the Expression of a Nuclear Matrix-Associated Protein is Correlated with Cellular Transformation," Proc. Natl. Acad. Sci. USA 88:6936-6940 (1991).
Ciejak et al., "Actively Transcribed Genes are Associated with the Nuclear Matrix," Nature 306:607-609 (1983).
Donat et al., "Unique Nuclear Matrix Protein Alterations in Head and Neck Squamous Cell Carcinomas: Intermediate Biomarker Candidates," Otolaryngol. Head Neck Surg. 114:387-393 (1996).
Fey et al., "The Nuclear Matrix: Defining Structural and Functional Roles," Eukaryotic Gene Expression, 1:127-143 (1991).
Fey et al., "Nuclear Matrix Proteins Reflect Cell Type of Origin in Cultured Human Cells," Proc. Natl. Acad. Sci. USA 85:121-125 (1988).
Fisher et al., "cDNA Sequencing of Nuclear Lamins A and C Reveals Primary and Secondary Structural Homology to Intermediate Filament Proteins," Proc. Natl. Acad. Sci. USA 83:6450-6454 (1986).
Getzenberg et al., "Bladder Cancer-Associated Nuclear Matrix Proteins," Cancer Res. 56:690-694 (1996).
Getzenberg et al., "Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate," Cancer Res. 51:6514-6520 (1991).
Getzenberg et al., "The Tissue Matrix: Cell Dynamics and Hormone Action," Endocr. Rev. :399-417 (1990).
Getzenberg et al., "Tissue Specificity of the Hormonal Response in Sex Accessory Tissues in Associated with Nuclear Matrix Protein Patterns," Molecular Endocrinology 1336-1342 (1990).
Greenfield et al., "Human Papillomavirus 16 E7 Protein Is Associated with the Nuclear Matrix," Proc. Natl. Acad. Sci. USA 88:11217-11221 (1991).
Honore et al., "Cloning of a cDNA Encoding a Novel Human Nuclear Phosphoprotein Belonging to the WD-40 Family," Gene 151:291-296 (1994).
Keesee et al., "Nuclear Matrix Proteins in Human Colon Cancer," Proc. Natl. Acad. Sci. USA 91:1913-1916 (1994).
Keesee et al., "Utilization of Nuclear Matrix Proteins for Cancer Diagnosis," Critical Reviews in Eukaryotic Gene Expression 6(2&3):189-214 (Jun 1996).
Khanuja et al., "Nuclear Matrix Proteins in Normal and Breast Cancer Cells", Cancer Research 53:3394-3398 (1993).
Ou et al., "Cloning and Characterization of a Novel Cellular Protein, TDP-43, That Binds to Human Immunodeficiency Virus Type 1 TAR DNA Sequence Motifs," J. of Virology 69:3584-3596 (1995).
Pillai, R., "Oncogene Expression and Prognosis in Cervical Cancer," Cancer Letters 59:171-175 (1991).
Partin et al., "Nuclear Matrix Protein Patterns in Human Benign Prostatic Hyperplasia and Prostate Cancer," Cancer Research 53:744-746 (1993).
Stein et al., "Oligodeoxynucleotides as Inhibitors of Gene Expression: A Review," Cancer Research 48:2659-2668 (1988).
Stuurman et al, "The Nuclear Matrix from Cells of Different Origin," Journal of Biological Chemistry 265:5460-5465 (1990).
Troyanovsky et al., "Characterization of the Human Gene Encoding Cytokeratin 17 and its Expression Pattern," European Journal of Cell Biology 59:127-137 (1992).
Wu et al., "Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region," The Journal of Biological Chemistry 270:14209-14213 (1995).
News Release; "Matritech Scientists Discover Specific Nuclear Matrix Proteins (NMPs) Associated with Cervical Cancer"; Aug. (1996).
Chiang et al., "Identification of a Tumor-Associated Antigen in Cervical Carcinoma by Two-Dimensional (Crossed) Immunoelectrophoresis," J. Natl. Cancer Inst., 58(1):43-48 (1977).
Adams et al., "Rapid cDNA Sequencing (Expressed Sequence Tags) From A Directionally Cloned Human Infant Brain cDNA Library," Nature Genetics, 4:373-380 (1993).
Nucifora et al., "Involvement of the AMLI Gene in the t(3;21) in Therapy-Related Leukemia and in Chronic Myeloid Leukemia in Blast Crisis," Blood, 81(10):2728-2734 (1993).
Lebel et al., "Lamin A is not Synthesized as a Larger Precursor Polypeptide," Biochemical and Biophysical Research Communications, 49(2):417-423(1987).
Keesee Susan K.
Obar Robert
Wu Ying-Jye
Huff Sheela
Matritech, Inc.
Reeves Julie E.
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