Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-05-24
1994-12-27
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 18, 436506, 436811, G01N 33573
Patent
active
053765338
ABSTRACT:
An epitope of 21-hydroxylase has been identified which specifically reacts with autoantibodies to 21-hydroxylase. This epitope immunoreacts with anti-adrenocortical autoantibodies characteristically present in patients having autoimmune Addison's disease. The peptide can be used in a specific, sensitive immunoassay for the detection of these autoantibodies in the diagnosis of Addison's disease. The immunoassay permits the diagnosis of autoimmune Addison's disease and has considerable value in the screening of persons at risk. Persons in the early phases or at clinical onset of any kind of adrenocortical disease can also be screened to exclude Addison's disease as a cause.
REFERENCES:
Picado-Leonard et al., Cloning and Sequence of the Human Gene for P450c17 (Steroid 17.alpha.-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21. DNA 6(5): 439-448, 1987.
Bednarek, J., J. Furmaniak, N. Wedlock, Y. Kiso, A. Baumann-Anticzak, S. Fowler, H. Krishnan, J. A. Craft, and B. Rees Smith (1992) "Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease" FEBS 309(1):51-55.
Winqvist, Ola, F. Anders Karlsson, and Olle Kampe (1992) "21-hydroxylase, a major autoantigen in idiopathic Addison's disease" The Lancet 339:1559-1562.
Krohn, Kai, Raivo Uibo, Einari Aavik, Park Peterson, and Katja Savilahti (1992) "Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17.alpha.-hydroxylase" The Lancet 339:770-773.
Maclaren, Noel K., and William J. Riley (1986) "Inherited Susceptibility to Autoimmune Addison's Disease Is Linked to Human Leukocyte Antigens-DR3 and/or DR4, except when Associated with Type 1 Autoimmune Polyglandular Syndrome" Journal of Clinical Endocrinology and Metabolism 62(3):455-459.
Neufeld, Michel, Noel K. Maclaren, and Robert M. Blizzard (1981) "Two Types of Autoimmune Addison's Disease Associated with Different Polyglandular Autoimmune (PGA) Syndromes" Medicine 60(5):355-362.
Davenport, John, Charles Kellerman, David Reiss, and Lawrence Harrison (1991) "Addison's Disease" AFP 43(4):1338-1342.
Oelkers, W., S. Diederich, and V. Bahr (1992) "Diagnosis and Therapy Surveillance in Addison's Disease: Rapid Adrenocorticotropin (ACTH) Test and Measurement of Plasma ACTH, Renin Activity and Aldosterone" Journal of Clinical Endocrinology and Metalbolism 75(1):259-264.
Freeman, M., and A. P. Weetman (1992) "T and B cell reactivity to adrenal antigens in autoimmune Addison's disease" Clin. exp. Immunol. 88:275-279.
Maclaren Noel K.
Song Yao H.
Scheiner Toni R.
University of Florida
Wortman Donna C.
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