Methods and compositions for the control of the flesh fly

Details Methods and compositions for the control of the flesh fly Methods and compositions for the control of the flesh fly

1994-02-07

1995-10-17

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530329, 536 221, 536 231, 536 235, A61K 3800, C07K 100, C07K 200, C07H 1900

Patent

active

054591309

ABSTRACT:
The subject invention concerns novel peptides which have the property of interfering with the biosynthesis of the enzyme trypsin and the biosynthesis of the hormone ecdysone. This property enables the use of these peptides to, for example, inhibit the formation of progeny in blood-ingesting insects, e.g., Neobellieria, since trypsin is an essential enzyme for food digestion which provides the essential building blocks for egg development in such insects.

REFERENCES:
patent: 5011909 (1991-04-01), Borovsky et al.
Borovsky, Dov et al. (1985) "Juvenile Hormone and 20-Hydroxyecdysone as Primary and Secondary Stimuli of Vitellogenesis in Aedes aegypti" Arch. Insect Biochem. Physiol. 2:75-90.
Borovsky, Dov et al. (1990) "Mosquito oostatic factor: a novel decapeptide modulating trypsin-like enzyme biosynthesis in the midgut" FASEB Journal 4:3015-3020.
Borovsky, Dov et al. (1992) "In vivo and In vitro Biosynthesis and Metabolism of Methyl Farnesoate, Juvenile Hormone III, and Juvenile Hormone III Acid in the Mosquito Aedes aegypti" J. Med. Ent. 29:619-629.
Borovsky, Dov et al. (1992) "Development of Specific RIA and ELISA to Study Trypsin Modulating Oostatic Factor in Mosquitoes" Arch. Insect. Biochem. Physiol. 21:13-21.
Borovsky, Dov et al. (1993) "Mass Spectrometry and Characterization of Aedes aegypti Trypsin Modulating Oostatic Factor (TMOF) and its Analogs" Insect Biochem. Mol. Biol. 27:703-712.
Woodhead, A. P. et al. (1989) "Primary Structure of Four Allatostatins: Neuropeptide Inhibitors of Juvenile Hormone Synthesis" Proc. Natl. Acad. Sci. USA 86:5997-6001.
Girardie, Josiane et al. (1989) "Amino Acid Sequence of Locust Neuroparsins" FEBS Letters 245:4-8.
Goltzene, Francine et al. (1978) "The Follicle Cell Epithelium of Maturing Ovaries of Locusta Migratoria: A New Biosynthetic Tissue for Ecdysone" Hoppe-Seyler's Z. Physiol. Chem. 359: 1427-1434.
Hagedorn, H. H. et al. (1975) "The Ovary as a source of .alpha.-ecdysone in an Adult Mosquito" Proc. Natl. Acad. Sci. USA 72:3255-3259.
Hanaoka, K. et al. (1980) "Brain Hormone Control of Ecdysone Secretion by the Ovary in a Mosquito" Elsevier/North Holland Biomedical Press 467-479.
Huybrechts, R. et al. (1977) "Induction of Vitellogenin Synthesis in Maile Sarcophaga Bullata By Ecdysterone" J. Insect Physiol. 23:1359-1362.
Bylemans et al. Regulatory Peptide 50(1) pp. 61-72 1994 (Abstract only).
Borovsky et al. The FASEB Journal vol. 4 pp. 3015-3020 Sep., 1990.

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