Methods and compositions for the attachment of proteins to lipos

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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435697, 436829, 514964, 514 2, A61K 3722

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053745485

ABSTRACT:
Novel fusions of a GPI signal domain and a polypeptide heterologous to the GPI signal domain donor polypeptide are provided for industrial use. Therapeutic administration of the GPI-linked product of the fusions enables the targeting of biological activity to cell membrane surfaces.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman
patent: 4480041 (1984-10-01), Myles et al.
patent: 4687661 (1987-08-01), Kikuchi et al.
patent: 5109113 (1992-04-01), Caras et al.
patent: 5223394 (1993-06-01), Wallner
J. R. Murphy et al, PNAS 83:8258 Nov. 1986.
Caras et al., "Analysis of the Signal for Attachment of a Glycophospholipid Membrane Anchor", J. Cell. Biol., 108: 1387-1396 (1989).
Seki et al., "Structural organization of the rat thy-1 gene", Nature, 313: 485-487 (1985).
Seki et al., "Hydrophobic Transmembrane Segment at the Carboxyl Terminus of Thy-1", Science, 227 649-651 (1985).
Schumacher et al., "Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence", Nature, 319: 407-409 (1986).
Kam et al., "Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA", P.N.A.S., 82, 8715-8719 (1985).
T. Moriuchi et al., "Rat Thy-1 antigen has a hydrophobic segment at the carboxyl terminus", FEBS Lett. 178(1):105-108 (1985).
Cross, G. A. M., "Structure of the variant glycoproteins and surface coat of Trypanosoma brucei", Philos Trans. R. Soc. London, Ser. B 307:3-12 (1984).
Weiss et al., "Isolation and characterization of a cDNA encoding a human liver/bone/kidney-type alkaline", Proc. Natl. Acad. Sci. USA 83:7182-7186 (1986).
Moran & Caras, "Fusion of Sequence Elements from Non-anchored Proteins to Generate a Fully Functional Signal for Glycophosphatidylinositol Membrane Anchor Attachment", J. Cell. Biol., 115(6): 1595-1600 (1991).
Moran et al., "Human recombinant soluble decay accelerating factor inhibits complement activation in vitro and in vivo," J. Immunol., 149: 1736-1743 (1992).
Low et al., "Phosphatidylinositol is the membrane-anchoring domain of the Thy-1 glycoprotein", Nature (London), 318: 62-64 (1985).
Cross, G. A. M., "Eukaryotic protein modification and membrane attachment via phosphatidylinositol", Cell, 48: 179-181 (1987).
Davitz et al., "Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC)," J. Exp. Med., 163: 1150-1161 (1985).
Low & Finean, "Specific release of plasma membrane enzyme by a phosphatidylinositol-specific phospholipase C", Biochimica et Biophysica Acta, 508: 565-570 (1978).
Futerman et al., "Physiochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ", Biochem. J., 226: 369-377 (1985).
Tse et al., "A Glycophospholipid Tail at the Carboxyl Terminus of the Thy-1 Glycoprotein of Neurons and Thymocytes", Science, 230:1003-1008 (1978).
Low, M. G. et al., "Covalently attached phosphatidylinositol as a hydrophobic anchor for membrane proteins", TIBS, 11: 212-215 (1986).
Caras, et al., "Signal for Attachment of a Phospholipid Membrane Anchor in Decay Accelerating Factor" Science 238:1280-1282 (Nov. 1987).
Caras, et al., "Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins", Nature 325:545-549 (Feb. 1987).
Fearon, "Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane", Proc. Natl. Acad. Sci. USA 76(11):5867-5871 (Nov. 1979).
Ferguson et al., "Glycosyl-sn-1,2-dimyristylphosphatidylinositol is Covalently Linked to Trypanosoma brucei Variant Surface Glycoprotein", J. Biol. Chem. 260(27):14547-14555 (1985).
Holers, et al., "Human C3b- and C4b-regulatory proteins: a new multi-gene family" Immunology Today 6(6):188-192 (1985).
Iida et al., "Complement Receptor is an Inhibitor of the Complement Cascade" J. Exp. Med. 153:1138-1150 (May 1981).
Iida et al., "Complement Receptor (CR1) Deficiency in Erythrocytes from Patients with Systemic Lupus Erythematosus" J. Exp. Med. 155:1427-1438 (May 1982).
Low, "Biochemistry of the glycosyl-phosphatidylinositol membrane protein anchors" Biochem. J. 244:1-13 (1987).
Medicus et al., "Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules" Eur. J. Immunol. 13:465-470 (1983).
Medof, et al., "Inhibition of Complement Activation on the Surface of Cells After Incorporation of Decay-Accelerating Factor (DAF) into their Membranes" J. Exp. Med. 160:1558-1578 (Nov. 1984).
Medof, et al., "Decay Accelerating Factor of Complement Is Anchored to Cells by a C-Terminal Glycolipid" Biochemistry 25:6740-6747 (1986).
Medof, et al., "Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement" Proc. Natl. Acad. Sci. USA 84:2007-2011 (Apr. 1987).
Medof, et al., "Control of the Function of Substrate-Bound C4b-C3b By the Complement Receptor CR1" J. Exp. Med. 159:1669-1685 (Jun. 1984).
Medof, et al., "Unique Role of the Complement Receptor CR1 in the Degradation of C3b Associated with Immune Complexes" J. Exp. Med. 156:1739--1754 (Dec. 1982).
Miyakawa, et al., "Defective Immune-Adherence (C3b) Receptor on Erythrocytes from Patients with Systemic Lupus Erythematosus" The Lancet 493-497 (Sep. 1981).
Nicholson-Weller, et al., "Isolation of a Human Erythrocyte Membrane Glycoprotein with Decay-Accelerating Activity for C3 Convertases of the Complement System" J. of Immunology 129(1):184-189 (Jul. 1982).
Nicholson-Weller, et al., "Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor" PNAS 80:5066-5070 (Aug. 1983).
Pangburn, et al., "Deficiency of an erythrocyte membrane protein with complement regulatory activity in paroxysmal nocturnal hemoglobinuria" PNAS 80:5430-5434 (Sep. 1983).
Pangburn, et al., "Paroxysmal Nocturnal Hemoglobinuria: Deficiency in Factor H-Like Functions of the Abnormal Erythrocytes" J. Exp. Med. 157:1971-1980 (Jun. 1983).
Ross, et al., "Generation of Three Different Fragments of Bound C3 with Purified Factor I or Serum" J. of Immunology 129:(5):2051-2060 (Nov. 1982).
Taylor, et al., "Decreased Complement Mediated Binding of Antibody/3H-dsDNA Immune Complexes to the Red Blood Cells of Patients with Systemic Lupus Erythematosus, Theumatoid Arthritis, and Mematologic Malignancies" Arthritis and Theumatism, 26 (6):736-744 (Jun. 1983).
Templeton et al., "Construction and Expression of a Recombinant DNA Gene Encoding a Polyomavirus Middle-Size Tumor Antigen with the Carboxyl Terminus of the Vesicular Stomatitis Virus Glycoprotein G" Mol. and Cell. Biol. 4(2):282-289 (Feb. 1984).
Wilson, et al., "Mode of Inheritance of Decreased C3b Receptors on Erythrocytes of Patients with Systemic Lupus Erythematosis" N. Engl. J. Med. 307(16):981-986 (Oct. 1982).

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