Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2008-07-01
2008-07-01
Martinell, James (Department: 1634)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120
Reexamination Certificate
active
07393665
ABSTRACT:
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like.
REFERENCES:
patent: 5149625 (1992-09-01), Church et al.
patent: 5451505 (1995-09-01), Dollinger
patent: 5635400 (1997-06-01), Brenner
patent: 5708153 (1998-01-01), Dower et al.
patent: 5770358 (1998-06-01), Dower et al.
patent: 5776737 (1998-07-01), Dunn
patent: 5846719 (1998-12-01), Brenner et al.
patent: 5935793 (1999-08-01), Wong
patent: 5981176 (1999-11-01), Wallace
patent: 6060596 (2000-05-01), Lerner et al.
patent: 6440667 (2002-08-01), Fodor et al.
patent: 6458530 (2002-10-01), Morris et al.
patent: 2003/0049616 (2003-03-01), Brenner et al.
patent: 2003/0096239 (2003-05-01), Gunderson et al.
patent: 2004/0259118 (2004-12-01), Macevicz
patent: 2006/0008824 (2006-01-01), Ronaghi et al.
patent: 2006/0019304 (2006-01-01), Hardenbol et al.
patent: WO02056014 (2002-07-01), None
patent: WO 02/097113 (2002-12-01), None
Gronostajski, “Site-specific DNA binding of nuclear factor I: effect of the spacer region,” Nucleic Acids Research, 15: 5545-5559 (1987).
Hensel et al, “Simultaneous identification of bacterial virulence genes by negative selection,” Science, 269: 400-403 (1995).
Shoemaker et al, “Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy,” Nature Genetics, 14: 450-456 (1996).
Wang et al, “Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples,” Nucleic Acids Research, 32: e76 (2004).
Crick et al, “Codes without commas,” Proc. Natl. Acad. Sci., 43: 416-421 (1957).
Ohlmeyer et al, “Complex synthetic chemical libraries indexed with molecular tags,” Proc. Natl. Acad. Sci., 90: 10922-10926 (1993).
Brenner et al, “In vitro cloning of complex mixtures of DNA on microbeads: Physical separation of differentially expressed cDNAs,” Proc. Natl. Acad. Sci., 97: 1665-1670 (2000).
Bozicevic Field & Francis LLP
Francis Carol L.
Martinell James
Population Genetics Technologies Ltd
Scherer David C.
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