Methods and compositions for suppressing allograft rejection in

Details Methods and compositions for suppressing allograft rejection in Methods and compositions for suppressing allograft rejection in

1995-06-05

1998-08-04

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4241851, 530350, A61K 3900, A61K 3938, C07K 100, C07K 1400

Patent

active

057889686

ABSTRACT:
Disclosed herein are methods for suppressing allograft rejection in mammals comprising administering to a mammal about to undergo or having undergone allograft surgery an agent selected from the group consisting of splenic tissue from an allograft donor, splenic extracts, cultured lymphocytes from an allograft donor, extracts of said cultured lymphocytes, MHC antigens, transplantation rejection suppressive fragments and analogs of MHC antigens in an oral or aerosol form. Also disclosed herein are pharmaceutical formulations and dosage forms for use in said methods.

REFERENCES:
patent: 5130297 (1992-07-01), Sharma et al.
Hancock, W.W. et al., Transplantation 55:1112-8, 1993.
Sayegh, M.H. et al., American Society of Histocompatability and Immunogenics, 18th Annual Meeting, Abstract, Oct. 1992.
Sayegh, M.H. et al., American Society of Nephrology, 25th Annual Meeting, Abstract, Nov. 1992.
Sayegh, M.H. et al., Proc. Nat'l. Acad. Sci. (u.S.A.) 89: 7762-9, 1992.
Sayegh, M.H. et al., Transplantation 53:162-6, 1992.
Wood et al., Transplantation 39(1):56-61, 1985.
Tilney, et al., J. Immunology 121(14):1480-1482, 1978.
Milton et al., J. Exp. Med. 161:98-112, 1985.
Remington's Pharmaceutical Sciences, 1633-1634, 1658-59, 1664-65, 1694-95, 1948.
Mason D.W. et al., Ann. Rev. Immunol. 4:119-145, 1986.
Mowat et al., Immunol. Today 8(3):93-98, 1987.
Chao et al., Immunogenetics 29:231-234, 1989.
Krensky et al., New Engl. J. Med. 32:510-517, 1990.
Wood, et al, 1985, Transplantation 39(1): 56-61.
Richman, et al, 1978, Journal of Immunology 140(2): 2429-2434.
Higgins, et al, 1988, Journal of Immunology 140(2): 440-445.
Newman, 1984, Therapeutic Aerosols, Clarke and Davis eds. Aerosols and The Lung 197-224.

Affiliated with

Also associated with

Rating

Methods and compositions for suppressing allograft rejection in does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions for suppressing allograft rejection in , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for suppressing allograft rejection in will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1174368