Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-11-03
2000-04-25
Peselev, Elli
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 35, 514 54, 514299, 514729, A61K 3170, A61K 31045, A61K 3144
Patent
active
060544333
ABSTRACT:
The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of .beta.-glucosidase activity or .beta.-glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions.
The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of .beta.-glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
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Elias Peter Michael
Holleran Walter Martin
Peselev Elli
The Regents of the University of California
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