Methods and compositions for stimulating neurite growth

Details Methods and compositions for stimulating neurite growth Methods and compositions for stimulating neurite growth

1996-11-13

1998-09-22

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514315, 514318, 514330, 514332, 514351, 5142372, 546139, 546192, 546193, 546194, 546245, 546256, 546300, 544129, C07D21160, A61K 31215

Patent

active

058114343

ABSTRACT:
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound and a neurotrophic factor, such as nerve growth factor (NGF). The methods comprise treating nerve cells with the above compositions or compositions comprising the compound without a neurotropic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

REFERENCES:
patent: 5192773 (1993-03-01), Armistead et al.
patent: 5543423 (1996-08-01), Zelle et al.
patent: 5614547 (1997-03-01), Hamilton et al.
patent: 5696135 (1997-12-01), Steiner et al.
J.P. Steiner et al., "High brain densities of the immunophilin FKBP colocalized with calcineurin," Nature, 358, pp. 584-587 (1992).
J.R. Hauske et al., "Design and synthesis of novel FKBP inhibitors," J. Med. Chem., 35, pp. 4284-4296 (1992).
B.G. Gold et al., "FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve," Soc. Neurosci. Abs., 19, p. 1316 (1993).
B.G. Gold et al., "The immunosuppressant FK506 increases the Rate of Axonal Regeneration in Rat Sciatic Nerve," J. Neuroscience, 15(11), pp. 7509-7516 (Nov. 1995).
W.E. Lyons et al., "Immunosupressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia," Proc. Natl. Acad. Sci. USA, 91, pp. 3191-3195 (Apr., 1994).
John Sharkey et al., "Immunophilins mediate the neuroprotective effects of FK506 of focal cerebral ischaemia." Nature, 371, pp. 336-339 (Sep. 22, 1994).
W.E. Lyons et al., "Neuronal regeneration enhances the expression of the immunophilin FKBP-12," J. Neuroscience., 15, pp. 2985-2994 (Apr., 1995).

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