Methods and compositions for stimulating neurite growth

Details Methods and compositions for stimulating neurite growth Methods and compositions for stimulating neurite growth

1995-06-08

2000-03-14

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514534, 514330, 514423, 514428, 514438, 514538, 514547, 514549, 514551, 514465, 514466, A61K 31235, A61K 3124, A61K 3140, A61K 3138

Patent

active

060373709

ABSTRACT:
The present invention relates to methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compositions comprise a neurotrophic amount of a compound which binds to the FK-506 binding protein (FKBP) and a neurotrophic factor, such as nerve growth factor NGF. The methods comprise treating nerve cells with the above-described compositions or compositions comprising the FKBP binding compound without a neurotrophic factor. The methods of this invention can be used to promote repair of neuronal damage caused by disease or physical trauma.

REFERENCES:
patent: 5330993 (1994-07-01), Armistead et al.
patent: 5614547 (1997-03-01), Hamilton et al.
J.R. Hauske et al., "Design and synthesis of novel FKBP inhibitors," J. Med. Chem., 35, pp. 4284-4296 (1992).
W.E. Lyons et al., "Immunosupressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory gaglia," Proc. Natl. Acad. Sci. USA, 91, pp. 3191-3195 (Apr., 1994).
W.E. Lyons et al., "Neuronal regeneration enhances the expression of the immunophilin FKBP-12," J. Neuroscience., 15, pp. 2985-2994 (Apr., 1995).
B.G. Gold et al., "FK506, an immunosuppressant, increases functional recovery and axonal regeneration in the rat following axotomy of the sciatic nerve," Soc. Neurosci. Abs., 19, p. 1316 (1993).

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