Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-02-28
2006-02-28
Nashed, Nashaat T. (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S252300, C435S320100, C530S350000
Reexamination Certificate
active
07005512
ABSTRACT:
The present invention discloses new muscle ring finger (MURF) proteins designate MURF-1, MURF-2 and MURF-3. The genes encoding these MURFs also are provided. MURFs interact with microtubules and thus play a role in cytoskeletal function, mitosis and cell growth. Thus, the uses of MURFs in diagnosis, treatment and drug screening, in particular relation to cardiomyopathies, are described.
REFERENCES:
patent: 5403711 (1995-04-01), Walder et al.
patent: 6060240 (2000-05-01), Kamb et al.
patent: 6096720 (2000-08-01), Love et al.
patent: 6248724 (2001-06-01), Moore et al.
patent: 2003/0166887 (2003-09-01), Yates et al.
patent: 2004/0018513 (2004-01-01), Downing et al.
patent: WO 00/58473 (2000-10-01), None
patent: WO 01/42302 (2001-06-01), None
patent: WO 01/55322 (2001-08-01), None
patent: WO 01/62767 (2001-08-01), None
Antin et al., “Taxol induces postmitotic myoblasts to assemble interdigitating microtubule-myosin arrays that exclude actin filaments,”J. Cell Biol., 90(2):300-308, 1981.
Bartkiewicz et al., “Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growht factor receptor,”J. Biol. Chem., 274(43):30887-30895, 1999.
Benjamin et al., “Temporospatial expression of the small HSP/alpha B-crystallin in cardiac and skeletal muscle during mouse development,”Dev. Dyn., 208(1):75-84, 1997.
Borden, “RING fingers and B-boxes: zinc-binding protein-proten interaction domains,”Biochem. Cell Biol., 76:351-358, 1998.
Buchner et al., “MID2, a homologue of the Optiz syndrome gene MID1: similarities in subcellular localization and differences in expression during development,”Hum.Mol. Genet., 8:1397-1407, 1999.
Cainarca et al., “Functional characterization of the Optiz syndrome gene product (midin): evidence for homodimerization and association with microtubules throughtout the cell cylce,”Hum. Mol. Genet., 8:1387-1396, 1999.
Cao et al., “Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution,”J. Cell Sci., 110(Pt 14):1563-1571, 1997.
Centner et al., “Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain,”J. Mol. Biol., 306:717-726, 2001.
Database EMBL accession No. AA840584.
Database EMBL accession No. AAS25842.
Database EMBL accession No. AAS25855.
Database EMBL accession No. AAU15855.
Database EMBL accession No. AAU15868.
Database EMBL accession No. AB030912.
Database EMBL accession No. AF294790.
Database EMBL accession No. AI644642.
Database EMBL accession No. AJ291712.
Database EMBL accession No. AJ291713.
Database EMBL accession No. AV006036.
Database EMBL accession No. AV006120.
De The et al., “The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR,”Cell, 66(4):675-684, 1991.
Francis et al., “Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons,”Neuron., 23:247-256, 1999.
Freemont, “Ubiquitination: RING for destruction?”Curr Biol., 10(2):R84-87, 2000.
Gleeson et al., “Doublecortin is a microtubule-associated protein, and is expressed widely by migrating neurons,”Neuron., 2:257-271, 1999.
Gunderson et al., “Generation of stable, posttranslationally modified microtubule array is an early event in myogenic differentitation,”J. Cell Biol., 109:2275-2288, 1989.
Hsieh et al., “The RING finger/B-Box factor TAM-1 and a retinoblastoma-like protein LIN-35 modualte context-dependent gene silencing in Caenorhabditis elegans,”Genes Dev., 13(22):2958-2970, 1999.
Kaech et al., “Cytoskeletal plasticity in cells expressing neuronal microtubule-associated proteins,”Neuron, 17(6):1189-1199, 1996.
Kaufman et al., “The M-cadherin catenin complex interacts with microtubules in skeletal muscle cells: implications for the fusion of myoblasts,”J. Cell Sci., 112:55-67, 1999.
Konno et al., EMBL database, Accession No. BB140247, published Jun. 28, 2000.
Kosik, “Tau protein and neurodegenration,”Mol. Neurobiol., 4(3-4):171-179, 1990.
Lee et al., “Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac skeletal muscle-specific expression of a single contractile protein gene,”J. Biol. Chem., 267(22):15875-15885, 1992.
Lee et al., EMBL database, Accession No. AA800245, published Apr. 30, 1998.
Li et al., “The association of Xenopus nuclear factor 7 with subcellular structures is dependent upon phosphorylation and specific domains,”Exp. Cell Res., 13(2):473-481, 1994.
Lo Nigro et al., “Point mutations and an intragenic deletion in LISI, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome,”Hum. Mol. Genet., 6(2):157-164, 1997.
Mangan and Olmsted, “A muscle-specific variant of the microtubule-associated protein 4 (MAP4) is required for myogenesis,”Dev., 122:771-781, 1996.
Marszalek et al., “Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II,”Proc. Nat'l Acad. Sci., 96(9):5043-5048, 1999.
Nguyen et al., “Overexpression of full- or partial-length MAP4 stabilizes microtubules and alters cell growth,”J. Cell Sci., 110 (Pt 2):281-294, 1997.
Nguyen et al., “Stabilization and functional modulation of microtubules by microtubule-associated protein 4,”Biol. Bull., 194(3):354-357, 1998.
Quaderi et al., “Optiz G/BBB syndrome, a defect in midline development, is due to mutation in a new RING finger gene on Xp22,”Nat. Gen., 17:285-291, 1997.
Rawls et al., “Overlapping functions of the myogenic bHLH genes MRF4 and MyoD revealed in double mutant mice,”Development, 125(13):2349-2358, 1998.
Sapir et al., “:LIS1 is a microtubule-associated phosphoprotein,”Eur. J. Biochem., 265(1):181-188, 1999.
Sapir et al., “Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit,”EMBO J., 16(23):6977-6984, 1997.
Sato et al., “Microtubule stabilization in pressure overload cardiac hypertrophy,”J. Cell Biol., 139:963-973, 1997.
Saurin et al., “Does this have a familiar RING?”TIBS, 21(6):208-214, 1996.
Schulze et al., “Postranslational modification and microtubule stability,”J. Cell Biol., 105:2167-2177, 1987.
Schweiger et al., “The Optiz syndrome gene product, MID1, associates with microtubules,”Proc. Nat'l Acad. Sci. USA, 96:2794-2799, 1999.
Sotiropoulos et al., “Signal-regulated activation of serum response factor is mediated by changes in actin dynamics,”Cell., 98: 159-169, 1999.
Spencer and Misra, “Expression of the serum response factor gene is regulated by serum response factor binding sites,”J. Biol. Chem., 271(28):16535-16543, 1996.
Spencer et al., “Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1,”J. Biol. Chem., 274(22):15686-15693, 1999.
Spencer et al., “Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein,”J. Cell Biol., 150(4):771-784, 2000.
Stone and Chambers, “Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells,”Exp. Cell. Res., 254: 110-119, 2000.
Supp et al., “Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries,”Dev., 126:5495-5504, 1999.
Takeda et al., “Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A / mice
Olson Eric N.
Spencer Jeffrey A.
Board of Regents , The University of Texas System
Fulbright & Jaworski
Moore William W.
Nashed Nashaat T.
LandOfFree
Methods and compositions for stabilizing microtubules and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and compositions for stabilizing microtubules and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions for stabilizing microtubules and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3642039